Abstract
Leishmaniasis, sleeping sickness (Human African Trypanosomiasis), Chagas disease (American Trypanosomiasis) and malaria are tropical parasitic diseases responsible for high mortality and morbidity each year in low-income countries. Due to the lack of vaccines and of safe, effective and affordable treatments, there is an urgent need to reinforce the existing therapeutic arsenal against these killers. One of the main opportunities is through the discovery of new molecules from natural origin. The gaps identified in the R process aiming to deliver new medicines for neglected diseases however also apply to natural products. A key review of the most promising antiprotozoal molecules recently discovered from natural resources is presented here together with a critical update on their current development status.
Current Organic Chemistry
Title: Natural Products for Neglected Diseases: A Review
Volume: 12 Issue: 8
Author(s): Jean-Robert Ioset
Affiliation:
Abstract: Leishmaniasis, sleeping sickness (Human African Trypanosomiasis), Chagas disease (American Trypanosomiasis) and malaria are tropical parasitic diseases responsible for high mortality and morbidity each year in low-income countries. Due to the lack of vaccines and of safe, effective and affordable treatments, there is an urgent need to reinforce the existing therapeutic arsenal against these killers. One of the main opportunities is through the discovery of new molecules from natural origin. The gaps identified in the R process aiming to deliver new medicines for neglected diseases however also apply to natural products. A key review of the most promising antiprotozoal molecules recently discovered from natural resources is presented here together with a critical update on their current development status.
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Cite this article as:
Ioset Jean-Robert, Natural Products for Neglected Diseases: A Review, Current Organic Chemistry 2008; 12 (8) . https://dx.doi.org/10.2174/138527208784577394
DOI https://dx.doi.org/10.2174/138527208784577394 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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