Abstract
The methylhydrazine derivative Procarbazine (PCZ) as monotherapy or in combination with CCNU and vincristine (PCV) was evaluated in a vast number of clinical trials and is still used in patients with high-grade and low-grade gliomas. The compound is an antineoplastic agent with multiple sites of action. It inhibits incorporation of small DNA precursors, as well as RNA and protein synthesis. PCZ can also directly damage DNA through an alkylation reaction. The drug is not cross-resistant with other mustard-type alkylating agents. As PCZ was in almost all trials used in a combination with CCNU and Vincristin, the efficacy can only be evaluated in the view of the PCV regimen. The published data suggest a role of PCV as a salvage regimen, especially in oligodendroglial tumors; however, well designed studies with high evidence are rare in all entities. This article summarizes the existing data with the goal to define the role of PCZ/PCV in modern neurooncology.
Keywords: Procarbazine, PCV, pharmacokinetics, chemotherapy, glioma, glioblastoma, anaplastic glioma, clinical trial
Current Medicinal Chemistry
Title: Procarbazine – A Traditional Drug in the Treatment of Malignant Gliomas
Volume: 15 Issue: 14
Author(s): Rainer Goerne, Ulrich Bogdahn and Peter Hau
Affiliation:
Keywords: Procarbazine, PCV, pharmacokinetics, chemotherapy, glioma, glioblastoma, anaplastic glioma, clinical trial
Abstract: The methylhydrazine derivative Procarbazine (PCZ) as monotherapy or in combination with CCNU and vincristine (PCV) was evaluated in a vast number of clinical trials and is still used in patients with high-grade and low-grade gliomas. The compound is an antineoplastic agent with multiple sites of action. It inhibits incorporation of small DNA precursors, as well as RNA and protein synthesis. PCZ can also directly damage DNA through an alkylation reaction. The drug is not cross-resistant with other mustard-type alkylating agents. As PCZ was in almost all trials used in a combination with CCNU and Vincristin, the efficacy can only be evaluated in the view of the PCV regimen. The published data suggest a role of PCV as a salvage regimen, especially in oligodendroglial tumors; however, well designed studies with high evidence are rare in all entities. This article summarizes the existing data with the goal to define the role of PCZ/PCV in modern neurooncology.
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Cite this article as:
Goerne Rainer, Bogdahn Ulrich and Hau Peter, Procarbazine – A Traditional Drug in the Treatment of Malignant Gliomas, Current Medicinal Chemistry 2008; 15 (14) . https://dx.doi.org/10.2174/092986708784567707
DOI https://dx.doi.org/10.2174/092986708784567707 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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