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Current Organic Synthesis

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ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

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Review Article

Arylidenemalononitriles as Versatile Synthons in Heterocyclic Synthesis

Author(s): Pannala Padmaja, B.V. Subba Reddy, Vinod G. Ugale and Pedavenkatagari Narayana Reddy*

Volume 19, Issue 5, 2022

Published on: 21 April, 2022

Page: [591 - 615] Pages: 25

DOI: 10.2174/1385272826666220113100746

Price: $65

Abstract

Background: Arylidenemalononitriles are valuable synthons for the construction of a variety of novel complex heterocyclic motifs, fused heterocycle derivatives, and spirocyclic compounds. They are versatile chemical intermediates and have increasing applications in industry, agriculture, medicine, and biological science.

Objective: The aim of this review is to highlight the preparation methods and reactions of arylidenemalononitriles in the synthesis of various heterocyclic compounds.

Conclusion: In this review, we have presented the application of arylidenemalononitriles to construct a variety of heterocycles. Various catalysts for the preparation of arylidnemalononitriles have been described.

Keywords: Arylidenemalononitriles, Malononitrile, Knoevenagel condensation, Multi-component reactions, Heterocyclic compounds, spirocyclic compounds.

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