Applications of Lipid-based Nanocarriers for Parenteral Drug Delivery

Title:Applications of Lipid-based Nanocarriers for Parenteral Drug Delivery

Volume: 29 Issue: 24

Author(s): Debora Santonocito*Carmelo Puglia

Affiliation:

• Department of Drug and Health Science, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy

Keywords: Lipid nanoparticles, phytocompounds, synthetic drugs, parenteral drug delivery, mRNA vaccine, Covid-19.

Abstract: This review describes the use of lipid-based nanocarriers (LNCs) for the parenteral delivery of pharmaceutical actives. Firstly, the two generations of LNCs, namely solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), are explained in terms of preparation, characterization and stability. Although the use of LNCs through parenteral administration has shown many benefits, their use is limited by opsonization, an immune process that causes their short half-life (3-5 min). Therefore, many strategies are discussed to realize “stealth” systems suitable for parenteral administration. The requirements and applications of parenteral lipid nanoparticles are reviewed for the delivery of natural compounds, synthetic drugs and genetic materials. Recently, the latter application has been of remarkable interest due to the numerous benefits of mRNA vaccines to fight the Covid-19 pandemic.

Cite this article as:

Santonocito Debora*, Puglia Carmelo, Applications of Lipid-based Nanocarriers for Parenteral Drug Delivery, Current Medicinal Chemistry 2022; 29 (24) . https://dx.doi.org/10.2174/0929867329666220104111949