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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Applications of Lipid-based Nanocarriers for Parenteral Drug Delivery

Author(s): Debora Santonocito* and Carmelo Puglia

Volume 29, Issue 24, 2022

Published on: 31 January, 2022

Page: [4152 - 4169] Pages: 18

DOI: 10.2174/0929867329666220104111949

Price: $65


This review describes the use of lipid-based nanocarriers (LNCs) for the parenteral delivery of pharmaceutical actives. Firstly, the two generations of LNCs, namely solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), are explained in terms of preparation, characterization and stability. Although the use of LNCs through parenteral administration has shown many benefits, their use is limited by opsonization, an immune process that causes their short half-life (3-5 min). Therefore, many strategies are discussed to realize “stealth” systems suitable for parenteral administration. The requirements and applications of parenteral lipid nanoparticles are reviewed for the delivery of natural compounds, synthetic drugs and genetic materials. Recently, the latter application has been of remarkable interest due to the numerous benefits of mRNA vaccines to fight the Covid-19 pandemic.

Keywords: Lipid nanoparticles, phytocompounds, synthetic drugs, parenteral drug delivery, mRNA vaccine, Covid-19.

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