Abstract
The identification of novel drug targets from genomic data involves the large-scale analysis of many protein sequences. Methods for automated structure and function prediction are an essential tool for this purpose. In this review we concentrate on the recent developments in the field of protein structure prediction and how these can be used to gain hints about the function of proteins. The current state-of-the-art is highlighted through recent community-wide experiments aimed at comparing different approaches. For structure prediction this allows the identification of key improvements to increase the crucial sequence to structure alignment needed for accurate models. Function prediction is a rapidly maturing field that is still being benchmarked. Definitions for protein function are presented and available methods, mostly concentrating on functional site descriptors and structural motifs, presented.
Keywords: Protein structure prediction, CASP, comparative modeling, fold recognition, function prediction, functional annotation
Current Pharmaceutical Design
Title: Large-Scale Prediction of Protein Structure and Function from Sequence
Volume: 12 Issue: 17
Author(s): S. C.E. Tosatto and S. Toppo
Affiliation:
Keywords: Protein structure prediction, CASP, comparative modeling, fold recognition, function prediction, functional annotation
Abstract: The identification of novel drug targets from genomic data involves the large-scale analysis of many protein sequences. Methods for automated structure and function prediction are an essential tool for this purpose. In this review we concentrate on the recent developments in the field of protein structure prediction and how these can be used to gain hints about the function of proteins. The current state-of-the-art is highlighted through recent community-wide experiments aimed at comparing different approaches. For structure prediction this allows the identification of key improvements to increase the crucial sequence to structure alignment needed for accurate models. Function prediction is a rapidly maturing field that is still being benchmarked. Definitions for protein function are presented and available methods, mostly concentrating on functional site descriptors and structural motifs, presented.
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Cite this article as:
Tosatto C.E. S. and Toppo S., Large-Scale Prediction of Protein Structure and Function from Sequence, Current Pharmaceutical Design 2006; 12 (17) . https://dx.doi.org/10.2174/138161206777585238
DOI https://dx.doi.org/10.2174/138161206777585238 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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