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Review Article

CAR-NK细胞用于癌症治疗:先天抗肿瘤反应的分子再设计

卷 22, 期 4, 2022

发表于: 12 January, 2022

页: [303 - 318] 页: 16

弟呕挨: 10.2174/1566523222666211217091724

价格: $65

摘要

嵌合抗原受体（CAR）已经成为一种强大的合成生物基础技术，在T细胞和NK细胞的应用中显示了多功能性。尽管CAR - T细胞在临床试验中取得了成功，但在不良事件和长期疗效方面仍有一些挑战需要解决。在治疗固体和液体肿瘤方面，NK细胞比T细胞具有内在优势，是一种有吸引力的选择。早期临床前和临床试验表明其至少有两个主要优势:提高安全性和由于其HLA独立性而在患者中的现成应用。由于CAR - NK转化为临床试验的早期阶段，目前可获得的数据有限。通过分析这些结果，似乎CAR - NK细胞可以降低癌症患者发生细胞因子释放综合征（CRS）或移植物抗宿主病（GvHD）的概率，减少安全隐患。此外，NK细胞治疗方法可能通过结合免疫检查点抑制剂和通过实施遗传回路来指导CAR-bearing细胞行为而得到促进。这篇综述提供了一个描述CAR技术修改NK细胞和翻译从临床前研究早期临床试验在这个新的免疫治疗领域。

关键词: 嵌合抗原受体，NK细胞，过继细胞转移，免疫治疗，癌症，基因治疗，合成生物学。

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