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New Emirates Medical Journal

Editor-in-Chief
ISSN (Online): 0250-6882

Review Article

Repurposing Ruxolitinib in Combating COVID-19: A Mini-review

Author(s): Inshia Begum, Fathima Murthuza, Juwairiya Syed Iqbaluddin and Hafsah Fatima Arsal*

Volume 3, Issue 1, 2022

Published on: 14 December, 2021

Article ID: e141221198907 Pages: 5

DOI: 10.2174/0250688202666210715141439

open_access

Abstract

Background: The pandemic caused by Coronavirus Disease 2019 (COVID-19), also known as Severe Acute Respiratory Syndrome-Related Coronavirus (SARS-CoV-2), is believed to be one of the greatest threats to global health in the 21st century. Recent collective evidence has warranted Ruxolitinib as a potential agent in recovery. Ruxolitinib is a potent and selective inhibitor of Jack kinase (JAK) 1 and 2 with modest to marked selectivity against tyrosine kinase 2 and JAK3, respectively.

Objective: The review aims to outline the current evidence regarding the repurposed treatment for COVID- 19 and to give an insight into the clinical trials. There has been considerable interest in introducing existing therapeutic agents against COVID-19 to reduce the severity of illness and ease the burden on public healthcare systems.

Methods: A literature search was conducted using keywords like ‘Ruxolitinib trial’ and ‘COVID-19 Ruxolitinib’ on PubMed, Google Scholar, Science Direct, and Cochrane databases to select research papers and articles on the topic published from January to October 2020. Inclusion criteria were restricted to articles on Ruxolitinib and COVID, whereas the exclusion criteria stipulated that any study done on COVID-19 involving mixed treatment regimen with Ruxolitinib and other drugs or any studies not pertinent to the purpose of the study were omitted.

Conclusion: Based on the successful outcomes of various researches conducted and clinical trials performed, the use of Ruxolitinib has shown significant improvement and faster clinical recovery among COVID-19 patients of varying severity of infection, advanced age and multiple comorbidities. This review provides an overview of various such studies with their promising outcomes.

Keywords: COVID-19, SARS-CoV-2, JAK1/2 inhibitors, Efficacy, Safety, Ruxolitinib, Coronavirus.

[1]
Coronavirus Update (Live). Available from: https://www.worldometers.info/coronavirus/
[2]
Goker Bagca B, Biray Avci C. The potential of JAK/STAT pathway inhibition by ruxolitinib in the treatment of COVID-19. Cytokine Growth Factor Rev 2020; 54: 51-62.
[http://dx.doi.org/10.1016/j.cytogfr.2020.06.013] [PMID: 32636055]
[3]
Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: Consider cytokine storm syndromes and immunosuppression. Lancet 2020; 395(10229): 1033-4.
[http://dx.doi.org/10.1016/S0140-6736(20)30628-0] [PMID: 32192578]
[4]
Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. The species severe acute respiratory syndrome-related coronavirus: Classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 2020; 5(4): 536-44.
[http://dx.doi.org/10.1038/s41564-020-0695-z] [PMID: 32123347]
[5]
Verstovsek S, Mesa RA, Gotlib J, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med 2012; 366(9): 799-807.
[http://dx.doi.org/10.1056/NEJMoa1110557] [PMID: 22375971]
[6]
Vannucchi AM, Kiladjian JJ, Griesshammer M, et al. Ruxolitinib versus standard therapy for the treatment of polycythemia vera. N Engl J Med 2015; 372(5): 426-35.
[http://dx.doi.org/10.1056/NEJMoa1409002] [PMID: 25629741]
[7]
Ahmed A, Merrill SA, Alsawah F, et al. Ruxolitinib in adult patients with secondary haemophagocytic lymphohistiocytosis: An open-label, single-centre, pilot trial. Lancet Haematol 2019; 6(12): e630-7.
[http://dx.doi.org/10.1016/S2352-3026(19)30156-5] [PMID: 31537486]
[8]
Zeiser R, von Bubnoff N, Butler J, et al. Ruxolitinib for glucocorticoid-refractory acute graft-versus-host disease. N Engl J Med 2020; 382(19): 1800-10.
[http://dx.doi.org/10.1056/NEJMoa1917635] [PMID: 32320566]
[9]
Saraceni F, Scortechini I, Mancini G, et al. Severe COVID-19 in a patient with chronic graft-versus-host disease after hematopoietic stem cell transplant successfully treated with ruxolitinib. Transpl Infect Dis 2021; 23(1)e13401
[http://dx.doi.org/10.1111/tid.13401] [PMID: 32629531]
[10]
Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020; 323(11): 1061-9.
[http://dx.doi.org/10.1001/jama.2020.1585] [PMID: 32031570]
[11]
Cao Y, Wei J, Zou L, et al. Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial. J Allergy Clin Immunol 2020; 146(1): 137-146.e3.
[http://dx.doi.org/10.1016/j.jaci.2020.05.019] [PMID: 32470486]
[12]
La Rosée F, Bremer HC, Gehrke I, et al. The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19 with severe systemic hyperinflammation. Leukemia 2020; 34(7): 1805-15.
[http://dx.doi.org/10.1038/s41375-020-0891-0] [PMID: 32518419]
[13]
Capochiani E, Frediani B, Iervasi G, et al. Ruxolitinib rapidly reduces acute respiratory distress syndrome in covid-19 disease. Analysis of data collection from RESPIRE protocol. Front Med (Lausanne) 2020; 7: 466.
[http://dx.doi.org/10.3389/fmed.2020.00466] [PMID: 32850921]
[14]
Chen L, Yu J, He W, et al. Risk factors for death in 1859 subjects with COVID-19. Leukemia 2020; 34(8): 2173-83.
[http://dx.doi.org/10.1038/s41375-020-0911-0] [PMID: 32546725]
[15]
Vannucchi AM, Sordi B, Morettini A, et al. Compassionate use of JAK1/2 inhibitor ruxolitinib for severe COVID-19: A prospective observational study. Leukemia 2020; 1-13.
[PMID: 32814839]
[16]
Neubauer A, Wiesmann T, Vogelmeier CF, et al. Ruxolitinib for the treatment of SARS-CoV-2 induced Acute Respiratory Distress Syndrome (ARDS). Leukemia 2020; 34(8): 2276-8.
[http://dx.doi.org/10.1038/s41375-020-0907-9] [PMID: 32555296]
[17]
Koschmieder S, Jost E, Cornelissen C, et al. Favorable COVID-19 course despite significant comorbidities in a ruxolitinib-treated patient with primary myelofibrosis. Eur J Haematol 2020; 105(5): 655-8.
[http://dx.doi.org/10.1111/ejh.13480] [PMID: 32593209]
[18]
La Rosée F, La Rosée P. Ruxolitinib in COVID-19 hyperinflammation and haematologic malignancies. Acta Haematol 2020; 1-3.
[PMID: 32818929]
[19]
Rojas P, Sarmiento M. JAK/STAT pathway inhibition may be a promising therapy for COVID-19 related hyperinflammation in hematologic patients. Acta Haematol 2020; 1-5.
[http://dx.doi.org/10.1159/000510179] [PMID: 32726783]
[20]
Gaspari V, Zengarini C, Greco S, Vangeli V, Mastroianni A. Side effects of ruxolitinib in patients with SARS-CoV-2 infection: Two case reports. Int J Antimicrob Agents 2020; 56(2)106023
[http://dx.doi.org/10.1016/j.ijantimicag.2020.106023] [PMID: 32450201]
[21]
Reoma LB, Trindade CJ, Monaco MC, et al. Fatal encephalopathy with wild-type JC virus and ruxolitinib therapy. Ann Neurol 2019; 86(6): 878-84.
[http://dx.doi.org/10.1002/ana.25608] [PMID: 31600832]
[22]
Ballesta B, González H, Martín V, Ballesta JJ. Fatal ruxolitinib-related JC virus meningitis. J Neurovirol 2017; 23(5): 783-5.
[http://dx.doi.org/10.1007/s13365-017-0558-4] [PMID: 28791626]
[23]
Tanaka T, Narazaki M, Kishimoto T. Immunotherapeutic implications of IL-6 blockade for cytokine storm. Immunotherapy 2016; 8(8): 959-70.
[http://dx.doi.org/10.2217/imt-2016-0020] [PMID: 27381687]

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