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Current Drug Safety


ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

Case Report

Amlodipine Induced Gum Hypertrophy: A Rare Case Report

Author(s): Suryanarayana Challa Reddy, Naresh Midha*, Vivek Chhabra, Deepak Kumar and Gopal Krishna Bohra

Volume 17, Issue 3, 2022

Published on: 14 March, 2022

Page: [281 - 283] Pages: 3

DOI: 10.2174/1574886316666211122125215

Price: $65


Background: DIGO or drug-induced gingival overgrowth occurs as a side effect of certain drugs. Until now, the etiology of drug-induced gingival overgrowth is not clearly understood.

Among the calcium channel blockers, nifedipine has been shown to be most frequently associated with drug-induced gingival hyperplasia. Amlodipine is a comparatively newer calcium channel blocker that with a longer duration of action and lesser side effects as compared to nifedipine. There are only certain case reports of amlodipine-induced gum hyperplasia.

Case presentation: We report a case of amlodipine-induced gum hyperplasia in a 66-year-old hypertensive patient taking amlodipine at a dose of 5 mg once a day. There was significant regression of gum hypertrophy after substitution of amlodipine by Losartan.

Conclusion: Amlodipine is one of the commonly prescribed antihypertensive drugs, and gingival hyperplasia is one overlooked side effect in patients taking amlodipine. Awareness of this potential side effect of amlodipine may be helpful to reduce the anxiety of patients and the cost of diagnostic procedures.

Keywords: Calcium channel blockers, drug induced gingival overgrowth, amlodipine, anticonvulsants, immunosuppressive, antihypertensive.

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Graphical Abstract
Dongari-Bagtzoglou A. Drug-associated gingival enlargement. J Periodontol 2004; 75(10): 1424-31.
[] [PMID: 15562922]
Amit B, Shalu BV. Gingival enlargement induced by anticonvulsants, calcium channel blockers and immunosuppressants: A review. IRJP 2012; 3: 116-9.
Seymour RA, Thomason JM, Ellis JS. The pathogenesis of drug-induced gingival overgrowth. J Clin Periodontol 1996; 23(3 Pt 1): 165-75.
[] [PMID: 8707974]
Lafzi A, Farahani RM, Shoja MA. Amlodipine-induced gingival hyperplasia. Med Oral Patol Oral Cir Bucal 2006; 11(6): E480-2.
[PMID: 17072250]
Russell RP. Side effects of calcium channel blockers. Hypertension 1988; 11(3 Pt 2): II42-4.
[PMID: 3280492]
Marshall RI, Bartold PM. A clinical review of drug-induced gingival overgrowths. Aust Dent J 1999; 44(4): 219-32.
[] [PMID: 10687229]
Livada R, Shiloah J. Calcium channel blocker-induced gingival enlargement. J Hum Hypertens 2014; 28(1): 10-4.
[] [PMID: 23739159]
Jorgensen MG. Prevalence of amlodipine-related gingival hyperplasia. J Periodontol 1997; 68(7): 676-8.
[] [PMID: 9249639]
Jose J, Santhosh YL, Naveen MR, Kumar V. Case report of amlodipine induced gingival hyperplasia—late onset at a low dose. Asian J Pharm Clin Res 2011; 4: 65-6.
Valsecchi R, Cainelli T. Gingival hyperplasia induced by erythromycin. Acta Derm Venereol 1992; 72(2): 157.
[PMID: 1350410]
Pradhan S, Mishra P, Joshi S. Drug induced gingival enlargement–a review. PGNM 2009; p. 8.
Gaur S, Agnihotri R. Is dental plaque the only etiological factor in Amlodipine induced gingival overgrowth? A systematic review of evidence. J Clin Exp Dent 2018; 10(6): e610-9.
[] [PMID: 29930781]
Hegde R, Kale R, Jain AS. Cyclosporine and amlodipine induced severe gingival overgrowth-etiopathogenesis and management of a case with electrocautery and carbon-dioxide (CO2) laser. J Oral Health Communi Dent 2012; 6: 34-42.
Jayanthi R, Mohammed Kalifa A, Archana BM. Prevalence and severity of amlodipine induced gingival overgrowth. Int J Contemp Med Res 2017; 4(2): 377-9.
Srivastava AK, Kundu D, Bandyopadhyay P, Pal AK. Management of amlodipine-induced gingival enlargement: Series of three cases. J Indian Soc Periodontol 2010; 14(4): 279-81.
[] [PMID: 21731258]
Routray SN, Mishra TK, Pattnaik UK, Satapathy C, Mishra CK, Behera M. Amlodipine-induced gingival hyperplasia. J Assoc Physicians India 2003; 51: 818-9.
[PMID: 14651149]
Grover V, Kapoor A, Marya CM. Amlodipine induced gingival hyperplasia. J Oral Health Community Dent 2007; 1: 19-22.
Prisant LM, Herman W. Calcium channel blocker induced gingival overgrowth. J Clin Hypertens (Greenwich) 2002; 4(4): 310-1.
[] [PMID: 12147940]

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