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Review Article

Cancer Treatment Evolution from Traditional Methods to Stem Cells and Gene Therapy

Author(s): Wenhua He, Qingxuan Li, Yan Lu, Dingyue Ju, Yu Gu, Kai Zhao and Chuanming Dong*

Volume 22, Issue 5, 2022

Published on: 03 January, 2022

Page: [368 - 385] Pages: 18

DOI: 10.2174/1566523221666211119110755

Price: $65

Abstract

Background: Cancer, a malignant tumor, is caused by the failure of the mechanism that controls cell growth and proliferation. Late clinical symptoms often manifest as lumps, pain, ulcers, and bleeding. Systemic symptoms include weight loss, fatigue, and loss of appetite. It is a major disease that threatens human life and health. How to treat cancer is a long-standing problem that needs to be overcome in the history of medicine.

Methods: Traditional tumor treatment methods are poorly targeted, and the side effects of treatment seriously damage the physical and mental health of patients. In recent years, with the advancement of medical science and technology, the research on gene combined with mesenchymal stem cells to treat tumors has been intensified. Mesenchymal stem cells carry genes to target cancer cells, which can achieve better therapeutic effects.

Discussion: In this study, we systematically review the cancer treatment evolution from traditional methods to novel approaches that include immunotherapy, nanotherapy, stem cell theapy, and gene therapy. We provide the latest review of the application status, clinical trials, and development prospects of mesenchymal stem cells and gene therapy for cancer, as well as their integration in cancer treatment. Mesenchymal stem cells are effective carriers carrying genes and provide new clinical ideas for tumor treatment.

Conclusion: This review focuses on the current status, application prospects, and challenges of mesenchymal stem cell combined gene therapy for cancer and provides new ideas for clinical research.

Keywords: Gene therapy, mesenchymal stem cells, cancer, clinical trials, gene carriers, viral vectors.

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