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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

General Review Article

Correlation of Oxidative Stress with Melasma: An Overview

Author(s): Shweta Katiyar* and Dhananjay Yadav*

Volume 28, Issue 3, 2022

Published on: 30 November, 2021

Page: [225 - 231] Pages: 7

DOI: 10.2174/1381612827666211104154928

Price: $65


Melasma is a hypermelanotic skin disorder characterized by dark brown macules of symmetrical sizes and shapes that develop over time. Apart from the multiple etiological factors for melasma, such as hormonal imbalances, thyroid dysfunction, drugs, and contraceptive pills, a new and significant cause has been discovered: the effect of oxidative stress. Oxidative stress is the result of disequilibrium between reactive oxygen species and antioxidants in the cells. It is a key element that can cause skin hypopigmentation or hyperpigmentation. The physiological significance of reactive oxygen species and its function in skin health are addressed in this study. The development process and pathophysiology of reactive oxygen species with melasma disorder are also highlighted and the advantages of integrating antioxidants in clinical and experimental environments are discussed.

Keywords: Melasma, oxidative stress, skin hyperpigmentation, reactive oxygen species, lipid peroxidation, DNA damage.

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