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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Recent Progress in Andrographolide Derivatization: Structural Modification and Biological Activity

Author(s): Wang Wang, Yueying Yang, Yang Liu, Dejuan Sun*, Hua Li* and Lixia Chen*

Volume 22, Issue 11, 2022

Published on: 13 January, 2022

Page: [1559 - 1584] Pages: 26

DOI: 10.2174/1389557521666211022150032

Price: $65

Abstract

Natural products have remarkable structural diversity and biological characteristics, providing researchers with more possibilities to develop novel drugs for disease therapeutics. Andrographolide, an ent-labdane diterpenoid from traditional Chinese medicines, Andrographis paniculata, exhibits a broad range of biological activities, which has been a hot area of research for several years. Up to now, lots of its derivatives with multiple bioactivities have been prepared through chemical modification. This review summarizes andrographolide derivatives prepared in the last ten years (2006-present), classifies them by different biological activities, and provides some discussion about the design of novel and potent derivatives.

Keywords: Andrographolide, modification, bioactivity, drug discovery, Andrographis paniculata, traditional chinese medicines.

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