Login Register Cart 0
Generic placeholder image

CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Sex-Related Differences in Polygraphic Parameters in a Population of Patients with Obstructive Sleep Apnea Syndrome

Author(s): Laura Buratti*, Chiara Rocchi, Viviana Totaro, Serena Broggi, Simona Lattanzi, Giovanna Viticchi, Lorenzo Falsetti and Mauro Silvestrini

Volume 21, Issue 6, 2022

Published on: 22 October, 2021

Page: [492 - 499] Pages: 8

DOI: 10.2174/1871527320666211022104140

Price: $65

Abstract

Background: Sex-related differences in the prevalence and clinical presentation of Obstructive Sleep Apnea Syndrome (OSAS) have been widely documented. The aim of this study was to investigate the influence of patients’ sex on polygraphic parameters with particular attention to sleep autonomic changes in a population of OSAS patients.

Methods: Sixty OSAS patients aged 55-65 years (30 men, 30 women) were enrolled. Sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI) and daytime sleepiness with the Epworth Sleepiness Scale (ESS). The presence of respiratory events and autonomic changes during the night was investigated by polygraphy.

Results: Similar main cardiovascular risk factors prevalence was observed in both men and women. We observed a significant difference in PSQI (higher in women, p=0.0001) and ESS (higher in men, p=0.004) scores. Snoring (p=0.033), supine AHI (p=0.004), T90 (p=0.021), LO2 (p=0.0001), LF/HF ratio and LF (p=0.0001) were significantly higher in men. Sex differences in PSQI mean score and LF/HF ratio variability were preserved in all the subgroups of OSA severity.

Conclusion: The influence of sex in modulating cardiovascular risk is a widely discussed topic. In our study, men showed more severe polygraphic parameters and an increase in LF/HF ratio compared to women. The results of our investigation suggest the relevance of delivering information about the different expressions of OSAS in men and women in order to improve diagnostic skills and in-depth prevention approaches.

Keywords: Gender, OSAS, heart rate variability, autonomic dysfunction, polygraphy, ESS.

« Previous Next »
[1]
Stöwhas AC, Lichtblau M, Bloch KE. Obstructive sleep apnea syndrome. Praxis (Bern 1994) 2019; 108: 111-7.
[2]
Shepertycky MR, Banno K, Kryger MH. Differences between men and women in the clinical presentation of patients diagnosed with obstructive sleep apnea syndrome. Sleep 2005; 28(3): 309-14.
[PMID: 16173651]
[3]
Basoglu OK, Tasbakan MS. Gender differences in clinical and polysomnographic features of obstructive sleep apnea: a clinical study of 2827 patients. Sleep Breath 2018; 22(1): 241-9.
[http://dx.doi.org/10.1007/s11325-017-1482-9] [PMID: 28197893]
[4]
Valipour A. Gender-related differences in the obstructive sleep apnea syndrome. Pneumologie 2012; 66(10): 584-8.
[http://dx.doi.org/10.1055/s-0032-1325664] [PMID: 22987326]
[5]
Jehan S, Auguste E, Zizi F, et al. Obstructive sleep apnea: Women’s perspective. J Sleep Med Disord 2016; 3(6): 1064.
[PMID: 28239685]
[6]
Yoshihisa A, Takeishi Y. Sleep disordered breathing and cardiovascular diseases. J Atheroscler Thromb 2019; 26(4): 315-27.
[http://dx.doi.org/10.5551/jat.RV17032] [PMID: 30814385]
[7]
Şener YZ, Okşul M, Akkaya F. Effects of obstructive sleep apnea and atrial fibrillation on blood pressure variability. Anatol J Cardiol 2019; 22(6): 338.
[PMID: 31789605]
[8]
Parati G, Ochoa JE, Bilo G, et al. Obstructive sleep apnea syndrome as a cause of resistant hypertension. Hypertens Res 2014; 37(7): 601-13.
[http://dx.doi.org/10.1038/hr.2014.80] [PMID: 24804613]
[9]
Buratti L, Cruciani C, Pulcini A, et al. Lacunar stroke and heart rate variability during sleep. Sleep Med 2020; 73: 23-8.
[http://dx.doi.org/10.1016/j.sleep.2020.04.005] [PMID: 32769029]
[10]
Rodriguez J, Blaber AP, Kneihsl M, et al. Poststroke alterations in heart rate variability during orthostatic challenge. Medicine (Baltimore) 2017; 96(14): e5989.
[http://dx.doi.org/10.1097/MD.0000000000005989] [PMID: 28383399]
[11]
Kernan WN, Ovbiagele B, Black HR, et al. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2014; 45(7): 2160-236.
[http://dx.doi.org/10.1161/STR.0000000000000024] [PMID: 24788967]
[12]
Buysse DJ, Reynolds CF III, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989; 28(2): 193-213.
[http://dx.doi.org/10.1016/0165-1781(89)90047-4] [PMID: 2748771]
[13]
Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 1991; 14(6): 540-5.
[http://dx.doi.org/10.1093/sleep/14.6.540] [PMID: 1798888]
[14]
Berry RB, Brooks R, Gamaldo C, et al. AASM Scoring Manual Updates for 2017 (Version 2.4). J Clin Sleep Med 2017; 13(5): 665-6.
[http://dx.doi.org/10.5664/jcsm.6576] [PMID: 28416048]
[15]
Chouchou F, Desseilles M. Heart rate variability: a tool to explore the sleeping brain? Front Neurosci 2014; 8: 402.
[http://dx.doi.org/10.3389/fnins.2014.00402] [PMID: 25565936]
[16]
Kim JB, Seo BS, Kim JH. Effect of arousal on sympathetic overactivity in patients with obstructive sleep apnea. Sleep Med 2019; 62: 86-91.
[http://dx.doi.org/10.1016/j.sleep.2019.01.044] [PMID: 30975558]
[17]
Variability HR. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Eur Heart J 1996; 17(3): 354-81.
[http://dx.doi.org/10.1093/oxfordjournals.eurheartj.a014868] [PMID: 8737210]
[18]
Bosi M, Milioli G, Riccardi S, et al. Arousal responses to respiratory events during sleep: the role of pulse wave amplitude. J Sleep Res 2018; 27(2): 259-67.
[http://dx.doi.org/10.1111/jsr.12593] [PMID: 28901049]
[19]
Zhao M, Guan L, Wang Y. The Association of autonomic nervous system function with ischemic stroke, and treatment strategies. Front Neurol 2020; 10: 1411.
[http://dx.doi.org/10.3389/fneur.2019.01411] [PMID: 32038467]
[20]
Lombardi C, Parati G, Cortelli P, et al. Daytime sleepiness and neural cardiac modulation in sleep-related breathing disorders. J Sleep Res 2008; 17(3): 263-70.
[http://dx.doi.org/10.1111/j.1365-2869.2008.00659.x] [PMID: 18503513]
[21]
Guggisberg AG, Hess CW, Mathis J. The significance of the sympathetic nervous system in the pathophysiology of periodic leg movements in sleep. Sleep 2007; 30(6): 755-66.
[http://dx.doi.org/10.1093/sleep/30.6.755] [PMID: 17580597]
[22]
McDermott M, Brown DL, Chervin RD. Sleep disorders and the risk of stroke. Expert Rev Neurother 2018; 18(7): 523-31.
[http://dx.doi.org/10.1080/14737175.2018.1489239] [PMID: 29902391]
[23]
Hepburn M, Bollu PC, French B, Sahota P. Sleep medicine: Stroke and sleep. Mo Med 2018; 115(6): 527-32.
[PMID: 30643347]
[24]
Buratti L, Viticchi G, Falsetti L, et al. Vascular impairment in Alzheimer’s disease: The role of obstructive sleep apnea. J Alzheimers Dis 2014; 38(2): 445-53.
[http://dx.doi.org/10.3233/JAD-131046] [PMID: 23985418]
[25]
Buratti L, Luzzi S, Petrelli C, et al. Obstructive sleep apnea syndrome: An emerging risk factor for dementia. CNS Neurol Disord Drug Targets 2016; 15(6): 678-82.
[http://dx.doi.org/10.2174/1871527315666160518123930] [PMID: 27189468]

Rights & Permissions Print Cite
Article Metrics
33
1
© 2024 Bentham Science Publishers | Privacy Policy