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Review Article

An Overview of the Synthetic Route to the Marketed Formulations of Pyrimidine: A Review

Author(s): Amit Kumar, Ankit Siwach and Prabhakar Verma*

Volume 22, Issue 6, 2022

Published on: 14 January, 2022

Page: [884 - 903] Pages: 20

DOI: 10.2174/1389557521666211008153329

Price: $65

Abstract

Pyrimidine and its derivatives are a very important class of heterocyclic compounds that show interesting applications in the field of medicinal chemistry. Pyrimidine not only plays an important role as an organic reaction intermediate but also has a wide range of interesting biological activities viz. antibacterial, antifungal, anticancer, anti-inflammatory, antiviral, and antiprotozoal activities, etc. Numerous methods are available for the formation of pyrimidine derivatives that have been reported in the literature. The advantage of pyrimidine as a starting material for different therapeutically potent derivatives has given momentum to this research. This review aims to report the new work on the synthesis of marketed drugs which consist pyrimidine moiety.

Keywords: Pyrimidine, heterocyclic compounds, marketed drugs, antimicrobial, anticancer, antiviral.

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