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Current Pharmacogenomics and Personalized Medicine

Editor-in-Chief

ISSN (Print): 1875-6921
ISSN (Online): 1875-6913

Meta-Analysis

Association of N-acetyltransferase-2 Polymorphism with Antituberculosis Induced Hepatotoxicity: A Meta-analysis

Author(s): Nur Farhana Mohamed Noor, Teh Lay Kek*, Mohd Arif Mohd Zim, Zamzurina Abu Bakar, Noor Izyani Zakaria, Muhammad Imran Lailanor and Mohd Zaki Salleh

Volume 18 , Issue 2 , 2021

Published on: 30 November, 2021

Page: [123 - 132] Pages: 10

DOI: 10.2174/1875692118666210928170636

Price: $65

Abstract

Background: N-acetyltransferase (NAT2) polymorphisms were reported to play important roles in Antituberculosis-Induced Hepatotoxicity (ATDIH). However, the allelic types with increased risks for ATDIH were inconsistent as most studies are of a small sample size.

Objective: The objective of the study was to conduct a meta-analysis to identify NAT2 alleles associated with increased risks of ATDIH.

Methods: Studies reported on NAT2 polymorphism with the risk of ATDIH were searched systematically in PubMed, Scopus, and the World of Sciences. Studies were included if they fulfilled the inclusion criteria and excluded accordingly. Quality assessments were done using Newcastle- Ottawa Score. Statistical analysis was performed using Review Manager version 5.3. Cochrane Q-statistic test and I2 statistic were used to assess and quantify heterogeneity.

Results: A total of 12 studies involving 580 cases and 3129 controls were included. NAT2 polymorphism was significantly associated with the risk of ATDIH with an Odd Ratio (OR) of 2.76 (1.86 – 4.10, 95% CI). Among the slow acetylators genotypes, NAT2*5/*7 carry the highest risk associated with ATDIH.

Conclusion: NAT2 polymorphism was significantly associated with ATDIH.

Keywords: Antituberculosis, hepatotoxicity, slow acetylator, NAT2 polymorphism, meta-analysis, personalized medicine, pharmacogenomic.

Graphical Abstract

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