Fixed Drug Eruptions Secondary to Fixed Drug Combination (Ofloxacin/Ornidazole): A Cross Sensitivity Case Report

Title:Fixed Drug Eruptions Secondary to Fixed Drug Combination (Ofloxacin/Ornidazole): A Cross Sensitivity Case Report

Volume: 16 Issue: 5

Author(s): Raushan Kumar Chaudhary, Anjali R. Metgudmath, Ramesh Bhandari, Satish S. Karoli*Uday Kumar R.

Affiliation:

• Department of Pharmacy Practice, KLE College of Pharmacy, A Constituent Unit of KLE Academy of Higher Education and Research, Belagavi, Karnataka,India

Keywords: Fixed drug eruption, fixed drug combination, fluoroquinolones, nitroimidazoles, cross sensitivity, spontaneous desensitization.

Abstract: Background: Fixed drug eruption (FDE) is an erythematous cutaneous patch caused by certain drugs through activation of immunologic reactions in the body. The onset of FDE is 30 minutes to 8 hours and is estimated to occur in upto 16-21% of all cutaneous reactions. The irrational combination of fluoroquinolones and nitroimidazole is the most prescribed drug for diarrhea in India, and the drug is found to cause FDE either individually or in combination. Cross sensitivity is the major issue associated with Fluoroquinolones and nitroimidazole.

Case Report: Our case is of a 45-year-old male who developed FDE due to a combination product of ofloxacin and ornidazole with past FDE history due to a combination product of norfloxacin and tinidazole. The patient presented with erythematous patches all over the body, swollen lips, mucosal erosion over the buccal cavity, and glans penis.

Discussion: The patient was successively treated after the withdrawal of the culprit drug with oral Antihistamines, corticosteroids, and other topical creams and gels, which correlates with the standard management of FDE.

Conclusion: Proper prescribing knowledge, documentation of drug allergies, and educating patient about allergic reaction play vital role to prevent future drug related problems.

Cite this article as:

Chaudhary Kumar Raushan, Metgudmath R. Anjali, Bhandari Ramesh, Karoli S. Satish*, R. Kumar Uday, Fixed Drug Eruptions Secondary to Fixed Drug Combination (Ofloxacin/Ornidazole): A Cross Sensitivity Case Report, Current Drug Therapy 2021; 16 (5) . https://dx.doi.org/10.2174/1574885516666210924124822