Sports-Related Brain Injury and Neurodegeneration in Athletes

Vipin    V.    Dhote; Muthu    Kumaradoss Mohan Maruga    Raja; Prem       Samundre; Supriya       Sharma; Shraddha       Anwikar; Aman    B.   Upaganlawar
Abstract

Sports deserve a special place in human life to impart healthy and refreshing wellbeing. However, sports activities, especially contact sports, renders athlete vulnerable to brain injuries. Athletes participating in a contact sport like boxing, rugby, American football, wrestling, and basketball are exposed to traumatic brain injuries (TBI) or concussions. The acute and chronic nature of these heterogeneous injuries provides a spectrum of dysfunctions that alters the neuronal, musculoskeletal, and behavioral responses of an athlete. Many sports-related brain injuries go unreported, but these head impacts trigger neurometabolic disruptions that contribute to long-term neuronal impairment. The pathophysiology of post-concussion and its underlying mechanisms are undergoing intense research. It also shed light on chronic disorders like Parkinson's disease, Alzheimer's disease, and dementia. In this review, we examined post-concussion neurobehavioral changes, tools for early detection of signs, and their impact on the athlete. Further, we discussed the role of nutritional supplements in ameliorating neuropsychiatric diseases in athletes.
Keywords: Traumatic brain injuries, Concussion, Parkinson's disease, Alzheimer's disease, Demntia, Nutraceuticals, Dietary supplements.
Graphical Abstract

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DOI https://dx.doi.org/10.2174/1874467214666210910114324	Print ISSN 1874-4672
Publisher Name Bentham Science Publisher	Online ISSN 1874-4702
Current Molecular Pharmacology

Sports-Related Brain Injury and Neurodegeneration in Athletes

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