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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Insights into Mechanism of NMD: Digging from the NMD-Related Protein Complexes

Author(s): Zhen-Ya Li, Xi-Song Ke, De-Pei Liu and Chih-Chuan Liang

Volume 13 , Issue 14 , 2006

Page: [1693 - 1705] Pages: 13

DOI: 10.2174/092986706777441995

Price: $65

Abstract

Nonsense-mediated RNA decay (NMD), an mRNA quality control mechanism, triggers degradation of mRNAs that contain premature termination codon (PTC) within their coding regions. NMD is a relatively conservative process that involves many trans-acting factors. The key domains for their function in NMD are conserved in evolution. These trans-acting factors are classified as different groups by their function in NMD. In addition, the mRNP formation is dynamic in NMD process because of sequential recruitment and interaction of these factors. To gain an insight into the mechanism of NMD, we dissect the mechanism of NMD based on the information on the structure, the regulation and interaction of these factors.

Keywords: Nonsense-mediated RNA decay, NMD-related protein complexes


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