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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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General Review Article

The Comprehensive Neural Mechanism of Oxytocin in Analgesia

Author(s): Liu-Nan Yang, Kai Chen, Xiao-Ping Yin*, Dan Liu* and Ling-Qiang Zhu*

Volume 20, Issue 1, 2022

Page: [147 - 157] Pages: 11

DOI: 10.2174/1570159X19666210826142107

Price: $65

Abstract

Oxytocin (OXT) is a nine amino acid neuropeptide hormone that has become one of the most intensively studied molecules in the past few decades. The vast majority of OXT is synthesized in the periventricular nucleus and supraoptic nucleus of the hypothalamus, and a few are synthesized in some peripheral organs (such as the uterus, ovaries, adrenal glands, thymus, pancreas, etc.) OXT modulates a series of physiological processes, including lactation, parturition, as well as some social behaviors. In addition, more and more attention has recently been focused on the analgesic effects of oxytocin. It has been reported that OXT can relieve tension and pain without other adverse effects. However, the critical role and detailed mechanism of OXT in analgesia remain unclear. This review aims to summarize the mechanism of OXT in analgesia and some ideas about the mechanism.

Keywords: Oxytocin, receptor, analgesia, nervous system, spinal cord, peripheral nervous system.

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