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Current Pharmacogenomics and Personalized Medicine

Editor-in-Chief

ISSN (Print): 1875-6921
ISSN (Online): 1875-6913

Review Article

Genomics and Pharmacogenomics of Age-related Hearing Loss

Author(s): Joaquin Guerra*, Vinogran Naidoo and Ramon Cacabelos

Volume 18 , Issue 2 , 2021

Published on: 22 August, 2021

Page: [72 - 90] Pages: 19

DOI: 10.2174/1875692118666210823115347

Price: $65

Abstract

Abstract: Age-related hearing loss (ARHL) or presbycusis shares common features with conditions related to senescence and neurodegeneration. In this review, we explore the linking of genes involved in such processes with presbycusis, that has been proven to share important relationships with genes involved in dementia (APOE and MTHFR), ototoxicity (the GST group), and pharmacogenetics (NAT2). In this regard, we propose the construction of pharmacogenetics for the presbycusis database that could help better control side effects in this particularly vulnerable population susceptible to neurodegenerative disorders. Moreover, preliminary epigenetics studies have recently identified links in human genes involved in ARHL, which could serve as biomarkers or as therapeutic targets.

Keywords: Presbycusis, genomics, pharmacogenomics, age-related hearing loss, APOE, NAT2, MTHFR.

Graphical Abstract

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