Abstract
The administration of heparins (unfractionated or fractionated) represents the current standard as anticoagulant treatment during percutaneous coronary intervention in different clinical settings (elective cases and acute coronary syndrome). Since the incidence of heparin-induced thrombocytopenia (HIT) is expected to range between 0.1 and 5%, the application of an appropriate anticoagulant agent has become a mandatory issue. This review will provide current pathophysiological insights of HIT as well as contemporary alternative anticoagulant strategies during PCI in patients with or at risk of HIT.
Keywords: Heparin-induced-thrombocytopenia, HIT, PCI, argatroban, bivalirudin, lepirudin, danaparoid, fondaparinux
Current Pharmaceutical Design
Title: Anticoagulation in Patients with Heparin-Induced Thrombocytopenia undergoing Percutaneous Coronary Angiography and Interventions
Volume: 14 Issue: 12
Author(s): Alexander Joost, Volkhard Kurowski and Peter W. Radke
Affiliation:
Keywords: Heparin-induced-thrombocytopenia, HIT, PCI, argatroban, bivalirudin, lepirudin, danaparoid, fondaparinux
Abstract: The administration of heparins (unfractionated or fractionated) represents the current standard as anticoagulant treatment during percutaneous coronary intervention in different clinical settings (elective cases and acute coronary syndrome). Since the incidence of heparin-induced thrombocytopenia (HIT) is expected to range between 0.1 and 5%, the application of an appropriate anticoagulant agent has become a mandatory issue. This review will provide current pathophysiological insights of HIT as well as contemporary alternative anticoagulant strategies during PCI in patients with or at risk of HIT.
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Cite this article as:
Joost Alexander, Kurowski Volkhard and Radke W. Peter, Anticoagulation in Patients with Heparin-Induced Thrombocytopenia undergoing Percutaneous Coronary Angiography and Interventions, Current Pharmaceutical Design 2008; 14 (12) . https://dx.doi.org/10.2174/138161208784246126
DOI https://dx.doi.org/10.2174/138161208784246126 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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