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Current Bioactive Compounds


ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Research Article

The Hepatoprotective Role of Warburgia salutaris and Iso-Mukaadial Acetate on Carbon Tetrachloride Intoxicated Rats Model

Author(s): Gideon Ayeni, Mthokozisi Blessing Cedric Simelane, Md. Shahidul Islam and Ofentse Jacob Pooe*

Volume 18, Issue 4, 2022

Published on: 15 August, 2021

Article ID: e160821195675 Pages: 6

DOI: 10.2174/1573407217666210816105252

Price: $65


Background: Medicinal plants, together with their isolated bioactive compounds, are known for their antioxidant properties, which constitute therapeutic agents that are routinely employed in the treatment of liver diseases.

Aims of the Study: The current study sought to explore the protective role of Warburgia salutaris and its isolated compound, iso-mukaadial acetate, against carbon tetrachloride (CCl4)-induced hepatic injury.

Methods: Thirty-five male Sprague Dawley rats were divided into seven groups of five animals each and injected with CCl4 to induce hepatic injury.

Results: Treatment with the crude extract of W. salutaris and iso-mukaadial acetate significantly reduced the levels of alkaline phosphatase, alanine and aspartate amino transaminases, and total bilirubin and malondialdehyde in a dose-dependent manner compared to untreated groups. Liver histology revealed a reduction in hepatic necrosis and inflammation.

Conclusion: The current investigation has demonstrated that W. salutaris extract and iso-mukaadial acetate could mitigate the acute liver injury inflicted by a hepatotoxic inducer in rats.

Keywords: Hepatoprotection, warburgia salutaris, iso-mukaadial acetate, medicinal plants, antioxidants, complementary alternative medicine, hepatoprotective, liver protection.

Graphical Abstract
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