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Current Medical Imaging


ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Research Article

Lung Nodule Detectability of Artificial Intelligence-assisted CT Image Reading in Lung Cancer Screening

Author(s): Yaping Zhang, Beibei Jiang, Lu Zhang, Marcel J.W. Greuter, Geertruida H. de Bock, Hao Zhang* and Xueqian Xie*

Volume 18, Issue 3, 2022

Published on: 06 August, 2021

Page: [327 - 334] Pages: 8

DOI: 10.2174/1573405617666210806125953

Price: $65


Background: Artificial Intelligence (AI)-based automatic lung nodule detection system improves the detection rate of nodules. It is important to evaluate the clinical value of the AI system by comparing AI-assisted nodule detection with actual radiology reports.

Objective: To compare the detection rate of lung nodules between the actual radiology reports and AI-assisted reading in lung cancer CT screening.

Methods: Participants in chest CT screening from November to December 2019 were retrospectively included. In the real-world radiologist observation, 14 residents and 15 radiologists participated in finalizing radiology reports. In AI-assisted reading, one resident and one radiologist reevaluated all subjects with the assistance of an AI system to locate and measure the detected lung nodules. A reading panel determined the type and number of detected lung nodules between these two methods.

Results: In 860 participants (57±7 years), the reading panel confirmed 250 patients with >1 solid nodule, while radiologists observed 131, lower than 247 by AI-assisted reading (p<0.001). The panel confirmed 111 patients with >1 non-solid nodule, whereas radiologist observation identified 28, lower than 110 by AI-assisted reading (p<0.001). The accuracy and sensitivity of radiologist observation for solid nodules were 86.2% and 52.4%, lower than 99.1% and 98.8% by AI-assisted reading, respectively. These metrics were 90.4% and 25.2% for non-solid nodules, lower than 98.8% and 99.1% by AI-assisted reading, respectively.

Conclusion: Comparing with the actual radiology reports, AI-assisted reading greatly improves the accuracy and sensitivity of nodule detection in chest CT, which benefits lung nodule detection, especially for non-solid nodules.

Keywords: Artificial intelligence, lung nodule, detectability, real-world study, radiologist observation, computed tomography.

Graphical Abstract
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