Current Developments in the Synthesis and Biological Activity of Aza-C-Nucleosides:Immucillins and Related Compounds

Title: Current Developments in the Synthesis and Biological Activity of Aza-C-Nucleosides:Immucillins and Related Compounds

Volume: 15 Issue: 10

Author(s): Pedro Merino, Tomas Tejero and Ignacio Delso

Affiliation:

• Departamento de Quimica Organica,Instituto de Ciencia de Materiales de Aragon, Universidad de Zaragoza-CSIC, E-50009 Zaragoza, Aragon, Spain.,Spain

Keywords: Immucillins, nucleoside analogues, pyrrolidines, malaria, glycosidase inhibitors, phosphorylase, nucleoside hydrolases

Abstract: This review will describe the recent advances in the field of aza-C-nucleosides with a particular emphasis on immucillins and related compounds. The review will cover both chemical and biological aspects concerning their preparation and/or occurrence in Nature as well as their biological properties which include glycosidase, glycosyl transferase, and nucleoside hydrolase and phosphorylase inhibition, among others. These enzymatic inhibitory properties are the basis for the potential use of the title compounds in viral and parasitic infections, cancer and genetic disorders.

Cite this article as:

Merino Pedro, Tejero Tomas and Delso Ignacio, Current Developments in the Synthesis and Biological Activity of Aza-C-Nucleosides:Immucillins and Related Compounds, Current Medicinal Chemistry 2008; 15(10) . https://dx.doi.org/10.2174/092986708784049612