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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Current Developments in the Synthesis and Biological Activity of Aza-C-Nucleosides:Immucillins and Related Compounds

Author(s): Pedro Merino, Tomas Tejero and Ignacio Delso

Volume 15 , Issue 10 , 2008

Page: [954 - 967] Pages: 14

DOI: 10.2174/092986708784049612

Price: $65


This review will describe the recent advances in the field of aza-C-nucleosides with a particular emphasis on immucillins and related compounds. The review will cover both chemical and biological aspects concerning their preparation and/or occurrence in Nature as well as their biological properties which include glycosidase, glycosyl transferase, and nucleoside hydrolase and phosphorylase inhibition, among others. These enzymatic inhibitory properties are the basis for the potential use of the title compounds in viral and parasitic infections, cancer and genetic disorders.

Keywords: Immucillins, nucleoside analogues, pyrrolidines, malaria, glycosidase inhibitors, phosphorylase, nucleoside hydrolases

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