Abstract
Protozoan parasites, such as those responsible for malaria and African Sleeping Sickness, represent a huge burden to the developing world. Current chemotherapy to combat these diseases is inadequate: antiquated, toxic and increasingly ineffective due to drug resistance. In this article, the potential usefulness of targeting key regulators of the parasite cell cycle will be discussed, paying particular attention to three families of protein kinases: Cyclin-dependent kinases, glycogen synthase kinases and Aurora kinases. This review shall outline their identification, which has been greatly accelerated by the availability of parasite genome data, their validation as bona fide regulators of the parasite cell cycle and current data on the availability and anti-parasite activity of inhibitors.
Keywords: Cyclin-dependent kinase, glycogen synthase kinase, aurora kinase, cell cycle, Trypanosoma, Leishmania, Plasmodium
Current Pharmaceutical Design
Title: Targeting the Cell Cycle in the Pursuit of Novel Chemotherapies Against Parasitic Protozoa
Volume: 14 Issue: 9
Author(s): Karen M. Grant
Affiliation:
Keywords: Cyclin-dependent kinase, glycogen synthase kinase, aurora kinase, cell cycle, Trypanosoma, Leishmania, Plasmodium
Abstract: Protozoan parasites, such as those responsible for malaria and African Sleeping Sickness, represent a huge burden to the developing world. Current chemotherapy to combat these diseases is inadequate: antiquated, toxic and increasingly ineffective due to drug resistance. In this article, the potential usefulness of targeting key regulators of the parasite cell cycle will be discussed, paying particular attention to three families of protein kinases: Cyclin-dependent kinases, glycogen synthase kinases and Aurora kinases. This review shall outline their identification, which has been greatly accelerated by the availability of parasite genome data, their validation as bona fide regulators of the parasite cell cycle and current data on the availability and anti-parasite activity of inhibitors.
Export Options
About this article
Cite this article as:
Grant M. Karen, Targeting the Cell Cycle in the Pursuit of Novel Chemotherapies Against Parasitic Protozoa, Current Pharmaceutical Design 2008; 14 (9) . https://dx.doi.org/10.2174/138161208784041042
DOI https://dx.doi.org/10.2174/138161208784041042 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Strategic Nanoparticle-Mediated Gene Transfer in Plants and Animals - a Novel Approach
Current Nanoscience Alzheimer’s and Type 2 Diabetes Treatment via Common Enzyme Targeting
CNS & Neurological Disorders - Drug Targets Editorial [Hot Topic: Novel Kinase Inhibitors in Cancer Therapy (Guest Editors: Ezra E.W. Cohen and Nikolai G. Rainov)]
Reviews on Recent Clinical Trials Overcoming the Blood-Brain Barrier for Chemotherapy: Limitations, Challenges and Rising Problems
Anti-Cancer Agents in Medicinal Chemistry Sesamol: An Efficient Antioxidant with Potential Therapeutic Benefits
Medicinal Chemistry New Mechanistic Insight on the PIM-1 Kinase Inhibitor AZD1208 Using Multidrug Resistant Human Erythroleukemia Cell Lines and Molecular Docking Simulations
Current Topics in Medicinal Chemistry Pharmacological Profile and Pharmacogenomics of Anti-Cancer Drugs Used for Targeted Therapy
Current Cancer Drug Targets Intracellular Bioinorganic Chemistry and Cross Talk Among Different -Omics
Current Topics in Medicinal Chemistry Stem Cell and Regenerative Medicine
Current Stem Cell Research & Therapy A Review of Current Animal Models of Osteoarthritis Pain
Current Pharmaceutical Biotechnology Growth Factors and Astrocytes Metabolism: Possible Roles for Platelet Derived Growth Factor
Medicinal Chemistry Pioglitazone Prevents Smoking Carcinogen-Induced Lung Tumor Development in Mice
Current Cancer Drug Targets Innovation in Contrast Agents for Magnetic Resonance Imaging
Current Medical Imaging Human Aurora / Ipl1p Related Kinases
Current Genomics The Anti-Cancer Effect of A3 Adenosine Receptor Agonists: A Novel, Targeted Therapy
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Long Term Complications in Pediatric Liver Transplant Recipients: What Every Pediatrician Should Know
Current Pediatric Reviews Microaspiration in Intubated Critically Ill Patients: Diagnosis and Prevention
Infectious Disorders - Drug Targets Invasive Aspergillosis in Children and Adolescents
Current Pharmaceutical Design HIV Protease Inhibitors Impact on Apoptosis
Medicinal Chemistry Role of Graphene Nano-Composites in Cancer Therapy: Theranostic Applications, Metabolic Fate and Toxicity Issues
Current Drug Metabolism