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Current Cancer Drug Targets

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

ALK-Positive Non-Small Cell Lung Cancer; Potential Combination Drug Treatments

Author(s): Shrestha Nensi and John Ashton*

Volume 21, Issue 9, 2021

Published on: 28 July, 2021

Page: [737 - 748] Pages: 12

DOI: 10.2174/1568009621666210729100647

Price: $65

Abstract

Advances in chromosomally rearranged ALK positive non-small cell lung cancer have been dramatic in only the last few years. Survival times have improved dramatically due to the introduction of ever more efficacious ALK inhibitors. These improvements have been due largely to improvements in blood-brain barrier penetration and the breadth of ligand binding pocket mutations against which the drugs are effective. However, the advances maybe slow due to the frequency of cancers with compound resistance mutations are appearing, suggesting the need to develop multiple ALK inhibitors to target different compound mutations.Another research area that promises to provide further gains is the use of drug combinations, with an ALK inhibitor combined with a drug targeting a “second driver” to overcome resistance. In this review, the range of secondary targets for ALK+ lung cancer and the potential for their clinical success are reviewed.

Keywords: ALK-positive NSCLC, combination treatment, ALK inhibitor, secondary targets, compound resistance, drug combinations.

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