Cancer Treatments Using Low-Temperature Plasma

Title:Cancer Treatments Using Low-Temperature Plasma

Volume: 28 Issue: 41

Author(s): Hiromasa Tanaka*, Masaaki Mizuno, Kenji Ishikawa, Shinya Toyokuni, Hiroaki Kajiyama, Fumitaka Kikkawa and Masaru Hori

Affiliation:

• Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan

Keywords: Low-temperature plasma, plasma medicine, plasma cancer therapy, reactive oxygen species (ROS), biochemical networks, plasma-activated medium.

Abstract: Low-temperature plasma (LTP) is a partially ionized gas that contains electrons, ions, radicals, light, etc. Recently, the bio-medical application of LTP has become a hot topic in plasma science and biological science. Cancer treatment with plasma is the most challenging topic in plasma bio-medical applications. Many in vitro and in vivo experiments have been conducted to investigate the anti-tumor effects of LTP. Extracellular reactive oxygen and nitrogen species (RONS) in plasma-activated solutions are key factors for the anti-tumor effects, and amino acid modifications by LTP may affect cellular responses. Intracellular RONS are also key factors for the anti-tumor effects. Various signaling pathways, such as p53 signaling pathways, survival and proliferation signaling pathways, and oxidative stress-dependent signaling pathways are activated by LTP.

Cite this article as:

Tanaka Hiromasa*, Mizuno Masaaki , Ishikawa Kenji, Toyokuni Shinya , Kajiyama Hiroaki , Kikkawa Fumitaka and Hori Masaru , Cancer Treatments Using Low-Temperature Plasma, Current Medicinal Chemistry 2021; 28 (41) . https://dx.doi.org/10.2174/0929867328666210629121731