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Infectious Disorders - Drug Targets


ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Case Report

West Nile Viral Meningoencephalitis in an Immunocompetent Female: A Case Report from Western Rajasthan, India

Author(s): Kumar S Abhishek, Sarika Tiwari, Prawin Kumar, Vijaya Lakshmi Nag*, Jaya Pamnani and Sarbesh Tiwari

Volume 21 , Issue 7 , 2021

Published on: 22 June, 2021

Article ID: e300821194092 Pages: 4

DOI: 10.2174/1871526521666210615132428

Price: $65


Background: West Nile virus (WNV) is a positive-sense single-stranded RNA virus of the family Flaviviridae and genus Flavivirus. The virus is transmitted primarily by the bite of Culex species mosquito and is of global concern. The infection is associated with a wide spectrum of signs and symptoms and is more fatal in the elderly, infants, and immunocompromised individuals.

Case Presentation: We report a case of WNV meningoencephalitis in an immunocompetent female who presented with features of acute meningitis with a 5-days history. After the radiological suspicion of viral meningoencephalitis, viral serology was performed and was reactive for IgM antibody against WNV, delaying the diagnosis for at least 5 days.

Conclusion: The purpose of this case report is to prime the treating physicians on the usefulness of viral serology in such a scenario. Viral serology is a simple and relatively rapid technique to diagnose or rule out the suspected viral cause of meningoencephalitis and minimize the time gap between diagnosis and start of supporting treatment wherever appropriate antivirals are not available for clinical use.

Keywords: Meningoencephalitis, immunocompetent, IgM ELISA, West Nile virus, viral serology, RNA.

Graphical Abstract

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