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Current Genomics

Editor-in-Chief

ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Genetic Variation and Atherosclerosis

Author(s): Erik Biros, Mirko Karan and Jonathan Golledge

Volume 9, Issue 1, 2008

Page: [29 - 42] Pages: 14

DOI: 10.2174/138920208783884856

Price: $65

Abstract

A family history of atherosclerosis is independently associated with an increased incidence of cardiovascular events. The genetic factors underlying the importance of inheritance in atherosclerosis are starting to be understood. Genetic variation, such as mutations or common polymorphisms has been shown to be involved in modulation of a range of risk factors, such as plasma lipoprotein levels, inflammation and vascular calcification. This review presents examples of present studies of the role of genetic polymorphism in atherosclerosis.

Keywords: Atherosclerosis, genetic polymorphism, risk factors


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