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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Fibrate-Associated Adverse Effects Beyond Muscle and Liver Toxicity

Author(s): M. S. Elisaf, M. Florentin, E. N. Liberopoulos and D. P. Mikhailidis

Volume 14, Issue 6, 2008

Page: [574 - 587] Pages: 14

DOI: 10.2174/138161208783885362

Price: $65


Fibrate derivatives have a 40-year history in the management of dyslipidemia. Although this class of drugs is generally well tolerated, several safety issues have arisen from their use. In the present article we review the literature describing side effects associated with the use of fibrates except for those that are liver and muscle related. These effects are less well known but are clinically relevant.

Keywords: Fibrates, Fibric acid derivatives, Peroxisome proliferator-activated receptors (PPAR), Side effects, Adverse effects, Renal effects, Thrombosis, Gallbladder disease

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