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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Proteomics and Cardiovascular Disease: An Update

Author(s): Alfonso Giovane, Francesco Paolo Mancini, Claudio Napoli and Maria Luisa Balestrieri

Volume 15 , Issue 6 , 2008

Page: [555 - 572] Pages: 18

DOI: 10.2174/092986708783769713

Price: $65

Abstract

Proteomics has unraveled important questions in the biology of cardiovascular disease and holds even greater promise for the development of novel diagnostic and prognostic biomarkers. This approach may establish early detection strategies, and monitor responses to therapies. Technological advances (most notably blue native polyacrylamide gel electrophoresis, electrospray ionization, matrix- assisted laser desorption/ionization (MALDI), analysis of MALDI-derived peptides in Time-of-Flight (TOF) analyzers, and multidimensional protein identification technology (MudPIT) and bioinformatics for data handling and interpretation allow a large-scale identification of peptide sequence and post-translational modifications. Moreover, combination of proteomic biomarkers with clinical phenotype, metabolite changes, and genetic haplotype information is promising for the physician assessment of individual cardiovascular risk profile.

Keywords: mass spectrometry, two-dimensional gel electrophoresis, cardiovascular disease, Proteomics


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