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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Anticancer Potential of Coumarin and its Derivatives

Author(s): Narayan Bhattarai, Anupa A. Kumbhar, Yuba Raj Pokharel and Paras Nath Yadav*

Volume 21, Issue 19, 2021

Published on: 05 April, 2021

Page: [2996 - 3029] Pages: 34

DOI: 10.2174/1389557521666210405160323

Price: $65


Coumarins are found in higher plants like Rutaceae and Umbelliferae and essential oils of cinnamon bark, cassia leaf, and lavender oil. Coumarin compounds show different biological properties, viz antimicrobial, antibacterial, antifungal, antioxidant, antitumor, anti-HIV, antihypertension, anticoagulant, anticancer, antiviral, anti-inflammatory, analgesics, antidiabetic, anti-depressive, and other bioactive properties. Coumarin and its derivatives possess anticancer activity against different types of cancers such as prostate, renal, breast, laryngeal, lung, colon, CNS, leukemia, malignant melanoma. In this review, current developments of coumarin-based anticancer agents viz simple coumarin, furanocoumarin, pyranocoumarin, pyrone-substituted coumarin, and their important derivatives have been discussed. The coumarin-triazole, coumarin-chalcone, coumarin-thiosemicarbazone derivatives, and coumarin-metal complexes have been found more potent than coumarin. Hence, further study and structural improvement on coumarin and its derivatives may lead to the design and development of more potent anticancer agents.

Keywords: Anticancer activity, coumarin, coumarin-metal complexes, furanocoumarin, pyranocoumarin, coumarin-triazole.

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