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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

循环肿瘤细胞和 DNA 作为胃肠癌预后和预测生物标志物的临床应用

卷 21, 期 8, 2021

发表于: 11 March, 2021

页: [676 - 688] 页: 13

弟呕挨: 10.2174/1568009621666210311090531

价格: $65

摘要

胃肠道 (GI) 癌症是全球最常见的癌症之一。 其发病机制涉及遗传和表观遗传机制。 用于诊断和筛查胃肠道癌症的常规方法通常是侵入性的并且具有其他局限性。 在个性化医疗时代，引入了一种称为液体活检的新型非侵入性方法来检测和管理胃肠道癌症，该方法侧重于分析循环肿瘤细胞 (CTC) 和循环无细胞肿瘤 DNA (ctDNA) . 几项研究表明，这种新方法可以提高对胃肠道肿瘤生物学的理解，并将导致临床管理的改进。 本综述的目的是探索 CTC 和 ctDNA 在胃肠道癌症患者中的临床应用。

关键词: 胃肠癌、液体活检、CTC、ctDNA、生物标志物、肿瘤生物学。

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