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Current Stem Cell Research & Therapy


ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Review Article

Advances in Stem Cells Transplantation for the Therapy of Parkinson’s Disease

Author(s): Xiansi Zeng, Wenshuo Geng, Jinjing Jia* and Zhanqi Wang

Volume 16, Issue 8, 2021

Published on: 09 March, 2021

Page: [958 - 969] Pages: 12

DOI: 10.2174/1574888X16666210309153949

Price: $65


Parkinson’s disease (PD) is a common neurodegenerative disease and is a major culprit that harms the health of elderly people. The main pathological feature is the progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. The current mainstream therapeutic strategies include surgical treatment and medicine substitute therapy. However, these treatment methods sometimes have limitations. Subsequently, the treatment with stem cells (SCs) transplantation has been gradually established. SCs is a kind of cell with self-renewal ability and multi-directional differentiation potential. Transplantation of SCs, including embryonic stem cells, adult stem cells (neural stem cells and mesenchymal stem cells) and induced pluripotent stem cells, have the ability to mediate nerve regeneration and restoration within the lesioned midbrain tissue, bringing hope for the treatment of PD. In this paper, we summarize the progress in therapeutic strategies of different types of SCs in PD treatment, with an emphasis on the advantages and limitations.

Keywords: Parkinson's disease, stem cells, cell therapy, neurodegenerative, substantia nigra pars compacta, striatum.

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