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Current Diabetes Reviews

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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

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Research Article

GST T1, M1, and IRS-1 G972R Genetic Variants Association to Gestational Diabetes Mellitus (GDM) in Egyptian Women: Linkage to Maternal Hyperglycemia

Author(s): Naglaa Fathy Barseem*, Essam Khattab, Ragab Dawood and Sally Mohamed

Volume 18, Issue 2, 2022

Published on: 19 February, 2021

Article ID: e021921191604 Pages: 8

DOI: 10.2174/1573399817666210219124628

Price: $65

Abstract

Background: Gestational Diabetes Mellitus (GDM) shares in part the pathogenic mechanisms of multiple genetic interactions. Some of the T2D susceptibility genes are encountered in association with GDM.

Objective: We aimed to investigate GST T1, M1, and G972R IRS-I gene polymorphisms with the risk of developing GDM.

Methods: In this randomized case-control study, pregnant women with GDM were genotyped by PCR analysis for glutathione s-transferase-T1, M1 variant polymorphisms. RFLP was done for the G972R IRS 1 gene. Their newborns were additionally assayed for the whole of the clinical, laboratory, and genetic aspects.

Results: The T allele IRS-1rs1801278 TT genotype was more frequently detected in GDM mothers in comparison to healthy control ones [for TT homozygous variant; OR(CI 95%): 2.05(1.09-3.87, p: 0.025)]. Furthermore, GST T1 null was significantly presented in GDM mothers than those of control mothers [OR (CI95%: 0.29 (0.084-1.02), p:0.04]. Added to the significant correlation of glycemic indices to clinical parameters of infants born to GDM, the M1-null genotype of GST was significantly correlated (p<0.05) to abnormal values of respiratory rates and 1 minute-APGAR score noted for extra NICU care.

Conclusion: Our results suggested that GST T1null and IRS-1 TT genotypic variants were claimed for GDM development among Egyptian women with a possible impact on their newly born infants.

Keywords: Gestational diabetes mellitus, maternal hyperglycemia, neonate, GST T, M1, IRS-1.

[1]
Alison N, Sarah P, Jennifer C. Gestational diabetes mellitus: A pragmatic approach to diagnosis and management. Gestational Diabetes Mellitus 2018; 47: 1-7.
[2]
Georgiou HM, Lappas M, Georgiou GM, et al. Screening for biomarkers predictive of gestational diabetes mellitus. Acta Diabetol 2008; 45(3): 157-65.
[http://dx.doi.org/10.1007/s00592-008-0037-8] [PMID: 18496643]
[3]
Chon S J, Kim S Y, Cho N R, Min D L, Hwang Y J, Mamura M. Association of variants in PPARγ2, IGF2BP2, and KCNQ1 with a susceptibility to gestational diabetes mellitus in a Korean population. Yonsei Med J 2013; 54: 352-7.
[4]
Boucher J. Insulin Receptor Signaling in Normal and Insulin-Resistant States. Cold Spring Harb Perspect Biol 2014; 6(1): a009191.
[5]
Wang Y, Chen L, Horswell R, et al. Racial differences in the association between gestational diabetes mellitus and risk of type 2 diabetes. J Womens Health (Larchmt) 2012; 21(6): 628-33.
[http://dx.doi.org/10.1089/jwh.2011.3318] [PMID: 22385105]
[6]
Kaburagi Y, Yamauchi T, Yamamoto-Honda R, et al. The mechanism of insulin-induced signal transduction mediated by the insulin receptor substrate family. Endocr J 1999; 46(Suppl.): S25-34.
[http://dx.doi.org/10.1507/endocrj.46.Suppl_S25] [PMID: 12054114]
[7]
Nasri HZ, Houde Ng K, Westgate MN, Hunt AT, Holmes LB. Malformations among infants of mothers with insulin-dependent diabetes: Is there a recognizable pattern of abnormalities? Birth Defects Res 2018; 110(2): 108-13.
[http://dx.doi.org/10.1002/bdr2.1155] [PMID: 29377640]
[8]
Gupta VH, Singh M, Amarapurkar DN, et al. Association of GST null genotypes with anti-tuberculosis drug induced hepatotoxicity in Western Indian population. Ann Hepatol 2013; 12(6): 959-65.
[http://dx.doi.org/10.1016/S1665-2681(19)31302-X] [PMID: 24114827]
[9]
Strange RC, Lear JT, Fryer AA. Glutathione S-transferase polymorphisms: Influence on susceptibility to cancer. Chem Biol Interact 1998; 111-112: 351-64.
[10]
Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol 2005; 45: 51-88.
[http://dx.doi.org/10.1146/annurev.pharmtox.45.120403.095857] [PMID: 15822171]
[11]
Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. J Ann Clin Biochem 1969; 6: 24-5.
[http://dx.doi.org/10.1177/000456326900600108]
[12]
Gonen B, Rubenstien AH. Determination of glycohemoglobin. Diabetologia 1978; 15: 1-5.
[http://dx.doi.org/10.1007/BF01219319] [PMID: 355029]
[13]
Donn SM, Sinha SK. Manual of Neonatal Respiratory Care. Switzerland: Springer International 2017; pp. 1-779.
[http://dx.doi.org/10.1007/978-3-319-39839-6]
[14]
Yahaya TO, Salisu T, Abdulrahman YB, et al. Update on the genetic and epigenetic etiology of gestational diabetes mellitus: A review. Egypt J Med Hum Genet 2020; 21: 13.
[http://dx.doi.org/10.1186/s43042-020-00054-8]
[15]
Groop L. Pathogenesis of type 2 diabetes: The relative contribution of insulin resistance and impaired insulin secretion. Int J Clin Pract Suppl 2000; 113(113): 3-13.
[PMID: 11965829]
[16]
Groop L, Lyssenko V. Genes and type 2 diabetes mellitus. Curr Diab Rep 2008; 8(3): 192-7.
[http://dx.doi.org/10.1007/s11892-008-0033-y] [PMID: 18625115]
[17]
Orhan O, Atalay MA, Orhan F, et al. Glutathione s-transferase m1 and t1 gene polymorphisms are not associated with increased risk of gestational diabetes mellitus development. West Indian Med J 2014; 63(4): 300-6.
[PMID: 25429472]
[18]
Williams M A, Qiu C, Dempsey J C, Luthy D A. Familial aggregation of type 2 diabetes and chronic hypertension in women with gestational diabetes mellitus. J Reprod Med 2003; 48(12): 955-62.
[19]
American diabetes association. Management of diabetes in pregnancy. Diabetes Care 2016; 39(Suppl. 1): S94-8.
[http://dx.doi.org/10.2337/dc16-S015] [PMID: 26696688]
[20]
Pappa KI, Gazouli M, Economou K, et al. Gestational diabetes mellitus shares polymorphisms of genes associated with insulin resistance and type 2 diabetes in the Greek population. Gynecol Endocrinol 2011; 27(4): 267-72.
[http://dx.doi.org/10.3109/09513590.2010.490609] [PMID: 20540670]
[21]
Shaat N, Ekelund M. Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus. Diabetologia 2004; 47(5): 878-84.
[22]
Tok EC, Ertunc D, Bilgin O, Erdal EM, Kaplanoglu M, Dilek S. Association of insulin receptor substrate-1 G972R variant with baseline characteristics of the patients with gestational diabetes mellitus. Am J Obstet Gynecol 2006; 194(3): 868-72.
[http://dx.doi.org/10.1016/j.ajog.2005.08.067] [PMID: 16522427]
[23]
Mattar R, Torloni MR, Betrán AP, Merialdi M. Obesity and pregnancy. Rev Bras Ginecol Obstet 2009; 31(3): 107-10.
[PMID: 19547884]
[24]
Karbownik-Lewinska M, Szosland J, Kokoszko-Bilska A, et al. Direct contribution of obesity to oxidative damage to macromolecules. Neuroendocrinol Lett 2012; 33(4): 453-61.
[PMID: 22936256]
[25]
Gelaleti RB, Damasceno DC, Salvadori DM, et al. IRS-1 gene polymorphism and DNA damage in pregnant women with diabetes or mild gestational hyperglycemia. Diabetol Metab Syndr 2015; 7: 30.
[http://dx.doi.org/10.1186/s13098-015-0026-3] [PMID: 25859280]
[26]
Simońska-Cichocka E, Gumprecht J, Zychma M, et al. The polymorphism in insulin receptor substrate-1 gene and birth weight in neonates at term. Endokrynol Pol 2008; 59(3): 212-6.
[PMID: 18615395]
[27]
Bezerra RMN, de Castro V, Sales T, et al. The Gly972Arg polymorphism in insulin receptor substrate-1 is associated with decreased birth weight in a population-based sample of Brazilian newborns. Diabetes Care 2002; 25(3): 550-3.
[http://dx.doi.org/10.2337/diacare.25.3.550] [PMID: 11874945]
[28]
Nicolosi BF, Vernini JM, Costa RA, et al. Maternal factors associated with hyperglycemia in pregnancy and perinatal outcomes: A Brazilian reference center cohort study. Diabetol Metab Syndr 2020; 12: 49.
[http://dx.doi.org/10.1186/s13098-020-00556-w] [PMID: 32518595]
[29]
Li Y, Li S, Zhai Q, et al. Association of GSTs polymorphisms with risk of gestational diabetes mellitus. Int J Clin Exp Pathol 2015; 8(11): 15191-7.
[PMID: 26823865]
[30]
Qui YH, Xu YL, Zhang WH. Effect of GSTM1, GSTT1, and GSTP1 IIe105Val polymorphisms on susceptibility to gestational diabetes mellitus. Genet Mol Res 2015; 15(2): 1-7.
[31]
Marginean C, Banescu CV, Marginean CO, Tripon F, Melit LE, Iancu M. Glutathione S-transferase (GSTM1, GSTT1) gene polymorphisms, maternal gestational weight cross-sectional study in Romanian mothers and their newborns. Rom J Morphol Embryol 2017; 58(4): 1-9.
[32]
Spaight C, Gross J, Horsch A, Puder JJ. Gestational Diabetes Mellitus. Endocr Dev 2016; 31: 163-78.
[http://dx.doi.org/10.1159/000439413] [PMID: 26824237]
[33]
Chiefari E, Arcidiacono B, Foti D, Brunetti A. Gestational diabetes mellitus: An updated overview. J Endocrinol Invest 2017; 40(9): 899-909.
[http://dx.doi.org/10.1007/s40618-016-0607-5] [PMID: 28283913]

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