Abstract
Biocatalysts or enzymes have a pivotal role in speeding up most of the biochemical reactions that drives life processes. Although substrate-specific and promising, there are some pitfalls that limit their use for wide application. To counteract the shortcomings, artificial enzymes possessing enzyme characteristics with additional qualities have been devised, and that kick-started in the late 2000s. This review aims to provide an overview of nanozymes, designing concepts, nanomaterials and applications. To begin with, the limitations encountered by natural enzymes and its replacement with nanozymes have been highlighted. Secondly, how nanozymes evolved in due course of time, their classification and engineering strategies have been briefly described. Most importantly, the engineering of nanozymes for improved catalytic activities has also been discussed. A clear distinction between the enzymatic-mimic for various clinical and bioimaging applications has been critically reviewed. With this rapidly emerging technology, there would be a great demand pertaining to scalability, biosafety, catalytic diversity and environmental impacts challenging the futuristic world.
Keywords: Nanozymes, ion-adsorption, surface-modification, oxido-reductases, superoxide-dismutase, antibacteria, theranostics, cellular imaging.
Current Nanoscience
Title:Disruptive Nanozyme Technology for Futuristic Bio-Medical and Bio-imaging Applications
Volume: 17 Issue: 6
Author(s): Lakshmipathy Muthukrishnan*
Affiliation:
- Department of Conservative Dentistry & Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Poonamallee High Road, Chennai, Tamil Nadu 600 077,India
Keywords: Nanozymes, ion-adsorption, surface-modification, oxido-reductases, superoxide-dismutase, antibacteria, theranostics, cellular imaging.
Abstract: Biocatalysts or enzymes have a pivotal role in speeding up most of the biochemical reactions that drives life processes. Although substrate-specific and promising, there are some pitfalls that limit their use for wide application. To counteract the shortcomings, artificial enzymes possessing enzyme characteristics with additional qualities have been devised, and that kick-started in the late 2000s. This review aims to provide an overview of nanozymes, designing concepts, nanomaterials and applications. To begin with, the limitations encountered by natural enzymes and its replacement with nanozymes have been highlighted. Secondly, how nanozymes evolved in due course of time, their classification and engineering strategies have been briefly described. Most importantly, the engineering of nanozymes for improved catalytic activities has also been discussed. A clear distinction between the enzymatic-mimic for various clinical and bioimaging applications has been critically reviewed. With this rapidly emerging technology, there would be a great demand pertaining to scalability, biosafety, catalytic diversity and environmental impacts challenging the futuristic world.
Export Options
About this article
Cite this article as:
Muthukrishnan Lakshmipathy *, Disruptive Nanozyme Technology for Futuristic Bio-Medical and Bio-imaging Applications, Current Nanoscience 2021; 17 (6) . https://dx.doi.org/10.2174/1573413717666210216120328
DOI https://dx.doi.org/10.2174/1573413717666210216120328 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Molecular Mechanisms of Pancreatic Cancer Dissemination: The Role of the Chemokine System
Current Pharmaceutical Design Seeking the 5th Base of DNA Using Chromatographic Methods of Analysis
Current Organic Chemistry Texaphyrins: Tumor Localizing Redox Active Expanded Porphyrins
Anti-Cancer Agents in Medicinal Chemistry Toxicities of Immunosuppressive Treatment of Autoimmune Neurologic Diseases
Current Neuropharmacology Silibinin – A Promising New Treatment for Cancer
Anti-Cancer Agents in Medicinal Chemistry miR-21, An Oncogenic Target miRNA for Cancer Therapy: Molecular Mechanisms and Recent Advancements in Chemo and Radio-resistance
Current Gene Therapy Current Management of Chordoma
Current Drug Therapy Ethnobotanical Survey of Medicinal Plants used to Treat Cardiovascular Disorders in Ghasemloo Valley of Urmia City
Cardiovascular & Hematological Agents in Medicinal Chemistry Key Epigenetic Events Involved in the Maintenance of Breast Cancer Stem Cells
Current Stem Cell Research & Therapy HSP60 as a Drug Target
Current Pharmaceutical Design Targeting Telomerase for Cancer Therapy
Current Cancer Therapy Reviews Systemic Delivery of Curcumin: 21st Century Solutions for an Ancient Conundrum
Current Drug Discovery Technologies Systemic Sclerosis: Clinical Manifestations
Current Rheumatology Reviews Natural Products Derived from Traditional Chinese Medicine as Novel Inhibitors of the Epidermal Growth Factor Receptor
Combinatorial Chemistry & High Throughput Screening Discovery of BRM Targeted Therapies: Novel Reactivation of an Anticancer Gene
Letters in Drug Design & Discovery Investigation on the Effects of Antimicrobial imidazo[2,1-b]thiazole Derivatives on the Genitourinary Microflora
Medicinal Chemistry Multifunctional Materials for Cancer Therapy: From Antitumoral Agents to Innovative Administration
Current Organic Chemistry The HOX Gene Network as a Potential Target for Cancer Therapy
Current Cancer Therapy Reviews Interaction Between Retinoids and Eicosanoids: Their Relevance to Cancer Chemoprevention
Current Nutrition & Food Science Co-delivery of Plasmid DNA and Antisense Oligodeoxyribonucleotide into Human Carcinoma Cells by Cationic Liposomes
Current Pharmaceutical Biotechnology