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Current Cancer Drug Targets


ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Review Article

The Role of RNA Modifications and RNA-modifying Proteins in Cancer Therapy and Drug Resistance

Author(s): Shaun Wood, Amber Willbanks and Jason X. Cheng*

Volume 21, Issue 4, 2021

Published on: 26 January, 2021

Page: [326 - 352] Pages: 27

DOI: 10.2174/1568009621666210127092828

Price: $65


The advent of new genome-wide sequencing technologies has uncovered abnormal RNA modifications and RNA editing in a variety of human cancers. The discovery of reversible RNA N6-methyladenosine (RNA: m6A) by fat mass and obesity-associated protein (FTO) demethylase has led to exponential publications on the pathophysiological functions of m6A and its corresponding RNA modifying proteins (RMPs) in the past decade. Some excellent reviews have summarized the recent progress in this field. Compared to the extent of research into RNA: m6A and DNA 5-methylcytosine (DNA: m5C), much less is known about other RNA modifications and their associated RMPs, such as the role of RNA: m5C and its RNA cytosine methyltransferases (RCMTs) in cancer therapy and drug resistance. In this review, we will summarize the recent progress surrounding the function, intramolecular distribution and subcellular localization of several major RNA modifications, including 5′ cap N7-methylguanosine (m7G) and 2′-O-methylation (Nm), m6A, m5C, A-to-I editing, and the associated RMPs. We will then discuss dysregulation of those RNA modifications and RMPs in cancer and their role in cancer therapy and drug resistance.

Keywords: 5′ cap, Myc, mTOR, drug resistance, N6-methyladenosine (m6A), adenosine-to-inosine editing (A-to-I), 5-methylcytosine (m5C), NOL1/NOP2/sun domain (NSUN).

Graphical Abstract
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