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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Apolipoprotein E Knockout Models

Author(s): Genovefa Kolovou, Katherine Anagnostopoulou, Dimitri P. Mikhailidis and Dennis V. Cokkinos

Volume 14, Issue 4, 2008

Page: [338 - 351] Pages: 14

DOI: 10.2174/138161208783497769

Price: $65

Abstract

Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they develop atherosclerosis in a short time. The current review considers lipid metabolism and inflammation as well as nutritional and pharmacological agents affecting atherosclerosis, using the apo E knock out mouse model.

Keywords: Apolipoprotein E, knock out, atherosclerosis


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