Background: In the last decades, the prevalence of obesity showed a significant increase in several countries. This fact is very worrying since there is an association between obesity and metabolic alterations, such as type II diabetes, hypertension, cardiovascular diseases, some types of cancer, and glucose intolerance. Knowledge of causes, preventive strategies, and treatment have been objects of studies by researchers in several centers.
Objective: The present paper aims to review some studies addressing the increase in the prevalence and incidence of obesity, diseases related to overweight, and procedures to reduce body fat. The primary focus of the presented work is the use of polymer systems as an alternative to the conventional pharmacological treatment of obesity, exploiting the natural and synthetic polymer systems that have excellent efficiency and can promote improvement to the existing therapies.
Results: The use of polymers presents the growing relevance as a new therapy and to the improvement of existing treatments. Among the polymers studied in the treatment of obesity, natural polymers such as chitosan and alginate have gained prominence. Synthetic polymer systems such as poly (ε-caprolactone) and poly (lactide-co-glycolide) were also studied for the treatment of obesity.
Conclusion: This mini-review reflects exclusive strategies that point out to polymers that can be an alternative to conventional pharmacological treatments or even as occupants in the treatment of obesity. Besides, we do believe that the most profound union between Polymers and Medical Science will allow us to mitigate this disease and all associated conditions, improving the quality of life, mainly of the poor populations from emerging countries.
[http://dx.doi.org/10.1111/obr.13058] [PMID: 32608177]
[http://dx.doi.org/10.1016/j.pharmthera.2016.10.013] [PMID: 27773783]
[http://dx.doi.org/10.1146/annurev-pharmtox-010716-104735] [PMID: 28061687]
[http://dx.doi.org/10.1111/obr.12932] [PMID: 31733033]
[http://dx.doi.org/10.1016/j.progpolymsci.2011.06.003] [PMID: 22125349]