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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Mini-Review Article

Therapeutic Properties of Several Chemical Compounds of Salvia officinalis L. in Alzheimer’s Disease

Author(s): Georgiana Uță, Denisa Ștefania Manolescu* and Speranța Avram

Volume 21, Issue 12, 2021

Published on: 30 December, 2020

Page: [1421 - 1430] Pages: 10

DOI: 10.2174/1389557521999201230200209

Price: $65


Background: Currently, the pharmacological management of Alzheimer's disease is based on several chemical structures, represented by acetylcholinesterase and N-methyl-D-aspartate (NMDA) receptor ligands, with still unclear molecular mechanisms and severe side effects. For this reason, a challenge for Alzheimer's disease treatment remains to identify new drugs with reduced side effects. Recently, the natural compounds, particularly, certain chemical compounds identified in the essential oil of peppermint, sage, grapes, sea buckthorn, have increased interest as possible therapeutics.

Objectives: In this paper, we have summarized data from the recent literature on several chemical compounds extracted from Salvia officinalis L., with therapeutic potential in Alzheimer's disease.

Methods: In addition to the wide range of experimental methods performed in vivo and in vitro, we also presented some in silico studies of medicinal compounds.

Results: Through this mini-review, we presented the latest information regarding the therapeutic characteristics of natural compounds isolated from Salvia officinalis L. in Alzheimer's disease.

Conclusion: Thus, based on the information presented, we can say that phytotherapy is a reliable therapeutic method in a neurodegenerative disease.

Keywords: Salvia officinalis L., alzheimer's disease, natural compounds, therapeutic effects, anti-cancer.

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