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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Green Enabling Technologies for Competitive Synthesis of Pharmaceutical Lead Compounds

Author(s): Silvia Tagliapietra, Arianna Binello, Fabio Bucciol, Vladimir Trukhan, Mariachiara Colia and Giancarlo Cravotto*

Volume 26, Issue 44, 2020

Page: [5700 - 5712] Pages: 13

DOI: 10.2174/1381612826999201116163951

Price: $65

Abstract

Combinations of different technologies are at the heart of the development and implementation of new, innovative processes and approaches for Industry 4.0 in the field of medicinal chemistry and drug discovery. Process intensification and advances in high-throughput synthetic techniques can dramatically improve reaction rates in processes for which slow kinetics represents a bottleneck. Easier access to target-based chemical library collections offers wider access to new leads for drug development. Green enabling technologies are a reliable ally for the design of environmentally friendly synthetic processes and more highly competitive pharmaceutical production. Mechanochemistry, microwaves, ultrasound and flow chemistry are mature techniques that can boast drug synthesis when properly integrated into the production chain. In this review, we selected examples from the literature of the last five years related to medicinal chemistry.

Keywords: Enabling technologies, pharmaceutical compounds, process intensification, high-throughput synthesis, mechanochemistry, microwaves, ultrasound, flow chemistry.

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