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Current Organic Synthesis

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ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Research Article

Synthesis of Novel bis-spirooxindoles Catalyzed by Magnetic Cobalt Ferrite Encapsulated MCM-41@MgO as a Solid Base

Author(s): Somaye Mohammadi and Hossein Naeimi*

Volume 18, Issue 2, 2021

Published on: 11 November, 2020

Page: [214 - 224] Pages: 11

DOI: 10.2174/1570179417666201111160600

Price: $65

Abstract

Aims and Objective: Synthesis of novel bis-spirooxindoles was carried out from isatins, two equivalents of malononitrile, and various derivatives of cyclohexanones.

Background: A facile one-pot and four-component reaction was investigated for the synthesis of novel bisspirooxindoles from different derivatives of isatins, two equivalents of malononitrile and various derivatives of cyclohexanone in the presence of magnetic CoFe2O4@MCM-41@MgO NPS catalyst under mild conditions.

Materials and Methods: Firstly, the magnetic CoFe2O4@MCM-41@MgO was prepared in three steps. Afterwards, the CoFe2O4@MCM-41@MgO was used as a base catalyst for the one-pot synthesis of bisspirooxindoles.

Results and Discussion: The procedure exhibited several benefits, an excellent yield of products, short reaction times, reusability, and recyclability of the nanocatalyst.

Conclusion: The structure of nanocatalyst was recognized by FT-IR, XRD, VSM, SEM, BET, and EDX techniques, and the structure of the organic products was determined by melting point, FT-IR, 1H NMR, 13C NMR, Mass spectra, and C.H.N analyses.

Keywords: Bis-spirooxindoles, MCM-41, isatin, malononitrile, cyclohexanone, C.H.N analyses.

Graphical Abstract
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