Abstract
Background: Cancer is a complex, multifactorial disease, and a major public health problem, as it is a leading cause of morbidity and mortality worldwide. Although treatments have significantly improved, still more effective drugs are searched. One source for these drugs is natural products (NPs). One NP that has shown anticancer activity is Limonene. However, the mechanisms of limonene's antiproliferative, anticancer and antineoplastic activity are not fully understood.
Objective: The objective of this study is to undertake a systematic review and meta-analysis of the literature on this subject.
Methods: A comprehensive literature search was performed using the Scopus, MEDLINE-PubMed, Web of Science, and Science Direct databases using the keywords: “limonene”, “cancer”, “neoplasm”, and “tumor”. The inclusion criteria were: in vivo and in vitro studies on the use of limonene in cancer published in English, Portuguese and Spanish until December 2019. Review articles, meta-analyses, abstracts, conference papers, editorials/ letters and case reports were excluded.
Results: The search identified 3568 articles, of which, 126 were selected for full reading, with 11 papers meeting the review criteria. Six more papers were added from the references of the initial 11 texts, giving a total of 17 papers. There was a high level of agreement in inclusion/exclusion (Kappa index > 80%). The risk of bias in the texts was shown to be high.
Conclusion: The meta-analysis suggests that limonene acts mainly on tumor regression induced apoptosis and is a promising natural product for use in the treatment of several types of cancer.
Keywords: Limonene, cancer, neoplasm, antitumoral activity, systematic review, meta-analysis.
Current Pharmaceutical Design
Title:Mechanism of Action of Limonene in Tumor Cells: A Systematic Review and Meta-Analysis
Volume: 27 Issue: 26
Author(s): Juliana de Vasconcelos C. Braz*, Fernanda O. de Carvalho, Daniele de Vasconcelos C. Meneses, Fernanda A.F. Calixto, Hericalizandra S.R. Santana, Isabella B. Almeida, Luana A.G. de Aquino, Adriano A. de Souza Araújo and Mairim R. Serafini
Affiliation:
- Postgraduate in Health Sciences, Federal University of Sergipe (UFS), Claudio Batista St, s/n, Sanatorio, Aracaju-SE,Brazil
Keywords: Limonene, cancer, neoplasm, antitumoral activity, systematic review, meta-analysis.
Abstract:
Background: Cancer is a complex, multifactorial disease, and a major public health problem, as it is a leading cause of morbidity and mortality worldwide. Although treatments have significantly improved, still more effective drugs are searched. One source for these drugs is natural products (NPs). One NP that has shown anticancer activity is Limonene. However, the mechanisms of limonene's antiproliferative, anticancer and antineoplastic activity are not fully understood.
Objective: The objective of this study is to undertake a systematic review and meta-analysis of the literature on this subject.
Methods: A comprehensive literature search was performed using the Scopus, MEDLINE-PubMed, Web of Science, and Science Direct databases using the keywords: “limonene”, “cancer”, “neoplasm”, and “tumor”. The inclusion criteria were: in vivo and in vitro studies on the use of limonene in cancer published in English, Portuguese and Spanish until December 2019. Review articles, meta-analyses, abstracts, conference papers, editorials/ letters and case reports were excluded.
Results: The search identified 3568 articles, of which, 126 were selected for full reading, with 11 papers meeting the review criteria. Six more papers were added from the references of the initial 11 texts, giving a total of 17 papers. There was a high level of agreement in inclusion/exclusion (Kappa index > 80%). The risk of bias in the texts was shown to be high.
Conclusion: The meta-analysis suggests that limonene acts mainly on tumor regression induced apoptosis and is a promising natural product for use in the treatment of several types of cancer.
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Cite this article as:
de Vasconcelos C. Braz Juliana *, de Carvalho O. Fernanda , de Vasconcelos C. Meneses Daniele, Calixto A.F. Fernanda, Santana S.R. Hericalizandra, Almeida B. Isabella , de Aquino A.G. Luana , de Souza Araújo A. Adriano and Serafini R. Mairim, Mechanism of Action of Limonene in Tumor Cells: A Systematic Review and Meta-Analysis, Current Pharmaceutical Design 2021; 27 (26) . https://dx.doi.org/10.2174/1381612826666201026152902
DOI https://dx.doi.org/10.2174/1381612826666201026152902 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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