Abstract
Nuclear receptors form a large family of ligand-dependent transcription factors that regulate diverse aspects of development and homeostasis. Several of these receptors have been demonstrated to play important roles in controlling biological processes that influence the development and clinical consequences of atherosclerosis. Because nuclear receptors are regulated by small molecules, they are potential targets for anti-atherogenic drugs. In this chapter, we review the use of mouse models to evaluate roles of nuclear receptors and their ligands in the pathogenesis and treatment of atherosclerosis.
Keywords: retinoid X receptors, cholesterol ester transport protein, PPAR Alpha, ABCA1 expression, VLDL level
Current Drug Targets
Title: Use of Mouse Models to Evaluate Roles of Nuclear Receptors and their Ligands in the Pathogenesis and Treatment of Atherosclerosis
Volume: 8 Issue: 12
Author(s): A. C. Li and C. K. Glass
Affiliation:
Keywords: retinoid X receptors, cholesterol ester transport protein, PPAR Alpha, ABCA1 expression, VLDL level
Abstract: Nuclear receptors form a large family of ligand-dependent transcription factors that regulate diverse aspects of development and homeostasis. Several of these receptors have been demonstrated to play important roles in controlling biological processes that influence the development and clinical consequences of atherosclerosis. Because nuclear receptors are regulated by small molecules, they are potential targets for anti-atherogenic drugs. In this chapter, we review the use of mouse models to evaluate roles of nuclear receptors and their ligands in the pathogenesis and treatment of atherosclerosis.
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Cite this article as:
Li C. A. and Glass K. C., Use of Mouse Models to Evaluate Roles of Nuclear Receptors and their Ligands in the Pathogenesis and Treatment of Atherosclerosis, Current Drug Targets 2007; 8 (12) . https://dx.doi.org/10.2174/138945007783220641
DOI https://dx.doi.org/10.2174/138945007783220641 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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