Towards the Development of a Broadly Protective Group A Streptococcal Vaccine Based on the Lipid-Core Peptide System

Title: Towards the Development of a Broadly Protective Group A Streptococcal Vaccine Based on the Lipid-Core Peptide System

Volume: 14 Issue: 28

Author(s): C. Olive, P. M. Moyle and I. Toth

Affiliation:

Keywords: Synthetic peptide vaccines, Lipid-Core Peptide system, multiepitope vaccines, self-adjuvanting, group A streptococcus, M protein

Abstract: Preclinical studies carried out over the last seven years by our group have focused on the development of a group A streptococcal (GAS) vaccine based on the antiphagocytic bacterial surface M protein using the Lipid-Core Peptide (LCP) system. This synthetic peptide vaccine delivery system has several advantages over other delivery systems including its self-adjuvanting properties and the ability to incorporate multiple peptide epitopes into a single vaccine. This review describes various vaccine delivery strategies including the LCP system, highlighting its functional properties and applications in vaccine research using data obtained from various LCP-based GAS vaccine candidates evaluated in murine models.

Cite this article as:

Olive C., Moyle M. P. and Toth I., Towards the Development of a Broadly Protective Group A Streptococcal Vaccine Based on the Lipid-Core Peptide System, Current Medicinal Chemistry 2007; 14 (28) . https://dx.doi.org/10.2174/092986707782794069