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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

Recent Achievements in Nucleophilic Decarboxylative Addition Reactions

Author(s): Serhii Melnykov*, Volodymyr Sukach and Mykhailo Vovk

Volume 24, Issue 19, 2020

Page: [2193 - 2215] Pages: 23

DOI: 10.2174/1385272824999200818181531

Price: $65

Abstract

Decarboxylative addition reactions are well known as an effective approach to C–C bonds formation due to the availability of starting reagents, ease of handling, and low environmental impact. This approach clearly demonstrated its potential for the synthesis of the variety of acyclic and heterocyclic compounds, including optically active ones. The significant amount of articles devoted to this topic published in recent years proves the importance of this approach in modern organic synthesis. In this review, the recent achievements in decarboxylative addition to C=C, C=N, and C=O bonds have been summarized and discussed over the last 6 years.

Keywords: Decarboxylative addition, regio- and stereoselective synthesis, enolization, metalo- and organocatalysis, C-C bond formation, nucleophilic addition.

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Graphical Abstract

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