Abstract
Nuclear transcription factor κB (NF-κB) was first discovered in 1986 in the nucleus of the B cell as an enhancer in the κ immunoglobulin chain. However, this factor has identified in the cytoplasm in the resting state. When activated in response to inflammatory stimuli, carcinogens, stress, ionizing radiation, and growth factors; NF-κB translocates to the nucleus where it upregulates the expression of over 400 different gene products linked with inflammation, cell survival, proliferation, invasion, and angiogenesis. The activation of NF- κB has now been linked with a variety of inflammatory diseases, including cancer and pulmonary, autoimmune, skin, neurodegenerative, and cardiovascular disorders. Indeed, constitutive NF-κB activation frequently correlates with the proliferation, survival, chemoresistance, radioresistance, and progression of various cancers. Hence, NF-κB has both diagnostic and prognostic applications. In addition, pharmaceutical companies are aggressively pursuing development of inhibitors of NF-κB with therapeutic potential. Thus within last decades this transcription factor, discovered serendipitously, has moved from “clone to clinic”.
Keywords: pulmonary disorders, Multiple sclerosis, Alzheimers disease, Neisseria gonorrhoeae, Antherosclerosis
Current Molecular Medicine
Title: Nuclear Factor-Kappa B: From Clone to Clinic
Volume: 7 Issue: 7
Author(s): Kwang Seok Ahn, Gautam Sethi and Bharat B. Aggarwal
Affiliation:
Keywords: pulmonary disorders, Multiple sclerosis, Alzheimers disease, Neisseria gonorrhoeae, Antherosclerosis
Abstract: Nuclear transcription factor κB (NF-κB) was first discovered in 1986 in the nucleus of the B cell as an enhancer in the κ immunoglobulin chain. However, this factor has identified in the cytoplasm in the resting state. When activated in response to inflammatory stimuli, carcinogens, stress, ionizing radiation, and growth factors; NF-κB translocates to the nucleus where it upregulates the expression of over 400 different gene products linked with inflammation, cell survival, proliferation, invasion, and angiogenesis. The activation of NF- κB has now been linked with a variety of inflammatory diseases, including cancer and pulmonary, autoimmune, skin, neurodegenerative, and cardiovascular disorders. Indeed, constitutive NF-κB activation frequently correlates with the proliferation, survival, chemoresistance, radioresistance, and progression of various cancers. Hence, NF-κB has both diagnostic and prognostic applications. In addition, pharmaceutical companies are aggressively pursuing development of inhibitors of NF-κB with therapeutic potential. Thus within last decades this transcription factor, discovered serendipitously, has moved from “clone to clinic”.
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Cite this article as:
Ahn Seok Kwang, Sethi Gautam and Aggarwal B. Bharat, Nuclear Factor-Kappa B: From Clone to Clinic, Current Molecular Medicine 2007; 7 (7) . https://dx.doi.org/10.2174/156652407782564363
DOI https://dx.doi.org/10.2174/156652407782564363 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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