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Current Drug Delivery

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ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

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Research Article

Chewable Tablets of Acacia catechu Extract, an Alternative to Betel (Paan) for Mouth Ulcers: Formulation and In vitro Evaluation

Author(s): Pooja Bhardwaj, Kodati Shailendra, Deep Shikha Sharma, Amit Sharma, Mangesh Pradeep Kulkarni, Sachin Kumar Singh, Vrinder Pal Singh, Gurvinder Singh, Pardeep Kumar and Rajesh Kumar*

Volume 18, Issue 4, 2021

Published on: 28 July, 2020

Page: [500 - 512] Pages: 13

DOI: 10.2174/1567201817999200728140352

Price: $65

Abstract

Objective: The objective of the current research work was to prepare chewable tablets having Acacia catechu extract useful for mouth ulcers using a 32 factorial design.

Methods: Acacia catechu heartwood extract was prepared using a reported method with some modifications. The extract was characterized using TLC against the catechin marker. Then, drug-excipient interaction studies were carried out. The mixture of drug and excipients was evaluated for pre-compression parameters. With the application of 32 factorial design, chewable tablets were prepared using direct compression technique. Prepared tablets were evaluated for post-compression parameters.

Results: In vitro drug release study of the developed formulations was investigated both in intact and crushed form of tablets. Based on the in vitro performance, the best formulations were selected (F6, F7 & F8 from intact and F1, F5 & F9 from the crushed group) and subjected to various kinetic models and evaluated for Chewing Difficulty Index (CDI).

Conclusion: The overall results revealed that the formulated chewable tablets complied with the standards and exhibited the satisfactory performance in terms of drug release, chewing difficulty index and other related parameters.

Keywords: Acacia catechu, extract, catechin, chewable tablet, direct compression, chewing difficulty index.

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