Introduction: Irritable Bowel Syndrome (IBS) is a chronic disorder. Considering its unknown etiology, the aim of IBS treatment is to control symptoms, and most patients are dissatisfied with current treatments. The World Health Organization (WHO) has emphasized, in its latest announcement in this regard, on the safe and effective use of traditional and complementary medicine in the health structures of countriesAims: The aim of the present study was to investigate the lifestyle of IBS patients from the perspective of Persian Medicine. Methods: This is a library study. At first, symptoms of IBS were first studied in databases and reference books of classical medicine and their Persian equivalents were extracted from PM sources. Then, we explained the total etiologies that were discussed for the occurrence of the causes, with respect to the principles of health care in PM. Finally, the collected information was categorized and analyzed. Results: Iranian physicians have presented their views on health preservation and disease prevention in the form of the six core principles. The influence of diet and lifestyle, sleep disturbances, eating habits, and physical activity have been found to be effective in causing this disease. Discussion: Many of the guidelines given by PM for preservation and restoration of health are incorporated into lifestyle-related topics. Some of these recommendations and guidelines, such as sleep, exercise, regular meals, and treatment of mental disorders have been supported with a number of new studies. Conclusion: Introducing PM strategies to control the symptoms or treatment of IBS may provide researchers with new clues.