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The Natural Products Journal

Editor-in-Chief

ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Review Article

The Multi Steps Synthetic Methods of (±)-Indolizidine 209D as an Amphibian Natural Product in the Family of Alkaloids

Author(s): Fatemeh Mohajer, Ghodsi Mohammadi Ziarani* and Fatemeh Taghipour

Volume 11, Issue 4, 2021

Published on: 07 June, 2020

Page: [448 - 462] Pages: 15

DOI: 10.2174/2210315510999200607180544

Price: $65

Abstract

(±)-Indolizidine 209D is one of the alkaloids isolated from the skin secretions of certain neotropical frogs and exhibit a range of pharmacological properties, including blocking neuromuscular transmission. Therefore, the synthesis of indolizidine 209D and more complex derivatives, have been the subject of several publications. The preparation pathways of indolizidine 209D and its derivatives are the subject of this review. In this paper, some highly regio- and stereoselective functionalization process were reviewed through the synthesis of the optically active (±)-indolizidine 209D.

Keywords: (±)-Indolizidine 209D, amphibian natural product, alkaloid derivatives, poisonous frogs, biologically active compounds, alkaloid total synthesis.

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