Abstract
Pharmacokinetics and drug metabolism play an important role as determinants of in vivo drug action. The CYP450 enzyme family plays a determinant role in the biotransformation of a vast number of structurally diverse drugs. Many drug interactions are a result of the inhibition or induction of CYP enzymes. The non-compartmental pharmacokinetic analysis is the most used method for analyzing data from a drug interaction study. Compartmental analysis can be also useful and sometimes more informative than non-compartmental analysis. Many efforts to reduce polypharmacy are important, and pharmacokinetic tools used to study the mechanism of drug-drug interactions may help in a better management of pharmacotherapy including the avoidance of clinically relevant drug interactions.
Keywords: Pharmacokinetics, Metabolism, Drug interactions
Current Clinical Pharmacology
Title: Pharmacokinetics and Metabolic Drug Interactions
Volume: 1 Issue: 1
Author(s): Sorin E. Leucuta and Laurian Vlase
Affiliation:
Keywords: Pharmacokinetics, Metabolism, Drug interactions
Abstract: Pharmacokinetics and drug metabolism play an important role as determinants of in vivo drug action. The CYP450 enzyme family plays a determinant role in the biotransformation of a vast number of structurally diverse drugs. Many drug interactions are a result of the inhibition or induction of CYP enzymes. The non-compartmental pharmacokinetic analysis is the most used method for analyzing data from a drug interaction study. Compartmental analysis can be also useful and sometimes more informative than non-compartmental analysis. Many efforts to reduce polypharmacy are important, and pharmacokinetic tools used to study the mechanism of drug-drug interactions may help in a better management of pharmacotherapy including the avoidance of clinically relevant drug interactions.
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Cite this article as:
Leucuta E. Sorin and Vlase Laurian, Pharmacokinetics and Metabolic Drug Interactions, Current Clinical Pharmacology 2006; 1 (1) . https://dx.doi.org/10.2174/157488406775268183
DOI https://dx.doi.org/10.2174/157488406775268183 |
Print ISSN 1574-8847 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3938 |
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